Title :

Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs

Author(s) :

Salzano, Giuseppina [Auteur]
Institut des Sciences Moléculaires d'Orsay [ISMO]
Wankar, Jitendra [Auteur]
National University of Ireland [Galway] [NUI Galway]
Ottani, Stefano [Auteur]
Villemagne, Baptiste [Auteur]
Médicaments et molécules pour les systèmes vivants - U 1177 [M2SV]
Baulard, Alain [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Willand, nicolas [Auteur]
Médicaments et molécules pour les systèmes vivants - U 1177 [M2SV]
Brodin, Priscille [Auteur]
Institut Pasteur de Lille
Manet, Ilse [Auteur]
Gref, Ruxandra [Auteur]
Institut des Sciences Moléculaires d'Orsay [ISMO]

Journal title :

International Journal of Pharmaceutics

Pages :

577-587

Publisher :

Elsevier

Publication date :

2017-10

ISSN :

0378-5173

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Countering TB prodrug resistance The arsenal of antibiotics for treating tuberculosis (TB) contains many prodrugs, such as ethionamide, which need activation by normal metabolism to release their toxic effects. Ethionamide ...
Show more >Countering TB prodrug resistance The arsenal of antibiotics for treating tuberculosis (TB) contains many prodrugs, such as ethionamide, which need activation by normal metabolism to release their toxic effects. Ethionamide is potentiated by small molecules. Blondiaux et al. screened for more potent analogs and identified a lead compound called SMARt-420. This small molecule inactivates a TetR-like repressor, EthR2, and boosts ethionamide activation. SMARt-420 successfully promoted clearance of multidrug-resistant strains of Mycobacterium tuberculosis from the lungs of mice. Science , this issue p. 1206Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Reprogrammation de la bioactivation des thioamides comme alternative antituberculeuse

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL