Role of CCL 18 in asthma and lung immunity

Tsicopoulos, A.; Chang, Y.; Ait Yahia, S.; de Nadai, P.; Chenivesse, C.

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1111/cea.12065

Titre :

Role of CCL 18 in asthma and lung immunity

Auteur(s) :

Tsicopoulos, A. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Chang, Y. [Auteur]
Ait Yahia, S. [Auteur]
de Nadai, P. [Auteur]
Chenivesse, C. [Auteur]

Titre de la revue :

Clinical and Experimental Allergy

Pagination :

716-722

Éditeur :

Wiley

Date de publication :

2013-06-21

ISSN :

0954-7894

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Summary Allergic asthma is a prototypic Th2 mediated disease, where chemokines orchestrate the inflammatory cell recruitment. Most chemokines have a pro‐inflammatory role. In this review, we focus on the potential role, ...
Lire la suite >Summary Allergic asthma is a prototypic Th2 mediated disease, where chemokines orchestrate the inflammatory cell recruitment. Most chemokines have a pro‐inflammatory role. In this review, we focus on the potential role, in asthma and lung immunity, of CCL 18 a chemokine both constitutively expressed at high levels in the lung and induced in inflammatory conditions. This chemokine is mainly produced by antigen presenting cells, and induced by Th2 type cytokines. The available data suggest that this chemokine may exhibit dual functions, with both pro‐ and anti‐inflammatory properties, the latter through its ability to generate adaptive regulatory T cells in healthy subjects, with a loss of function in allergic patients. However, the functional implications are at the moment hampered by the lack of data on the nature of its putative receptor, and the absence of murine orthologue.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL

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