Title :

Obstetrical outcome and treatments in seronegative primary APS: data from European retrospective study

Author(s) :

Abisror, Noemie [Auteur]
CHU Saint-Antoine [AP-HP]
Nguyen, Yann [Auteur]
Marozio, Luca [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Valverde, Enrique [Auteur]
Udry, Sebastian [Auteur]
Pleguezuelo, Daniel [Auteur]
Hospital Universitario 12 de Octubre [Madrid]
Billoir, Paul [Auteur]
Service de Médecine Interne [CHU Rouen]
Mayer-Pickel, Karoline [Auteur]
Medical University of Graz = Medizinische Universität Graz
Urbanski, Geoffrey [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Zigon, Polona [Auteur]
University Medical Centre Ljubljana [Ljubljana, Slovenia] [UMCL]
de Moreuil, Claire [Auteur]
Groupe d'Etude de la Thrombose de Bretagne Occidentale [GETBO]
Hôpital de la Cavale Blanche - CHRU Brest [CHU - BREST ]
Hoxha, Ariela [Auteur]
Azienda Ospedale Università di Padova = Hospital-University of Padua [AOUP]
Bezanahary, Holy [Auteur]
CHU Limoges
Carbillon, Lionel [Auteur]
Kayem, Gilles [Auteur]
Sorbonne Université - Faculté de Médecine [SU FM]
CHU Trousseau [APHP]
Bornes, Marie [Auteur]
Sorbonne Université - Faculté de Médecine [SU FM]
CHU Tenon [AP-HP]
Yelnik, Cecile [Auteur]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Centre de référence des maladies auto-immunes systémiques rares du Nord et Nord Ouest [CHRU Lille]
Johanet, Cathererine [Auteur]
Sorbonne Université - Faculté de Médecine [SU FM]
CHU Saint-Antoine [AP-HP]
Nicaise-Roland, Pascale [Auteur]
Unité Fonctionnelles d′Immunologie [CHU Bichat]
Lambert, Marc [Auteur]
Centre de référence des maladies auto-immunes systémiques rares du Nord et Nord Ouest [CHRU Lille]
Salle, Valéry [Auteur]
CHU Amiens-Picardie
Latino, Omar [Auteur]
Hachulla, Eric [Auteur]
Centre de référence des maladies auto-immunes systémiques rares du Nord et Nord Ouest [CHRU Lille]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Benedetto, Chiara [Auteur]
Università degli studi di Torino = University of Turin [UNITO]
Bourrienne, Marie [Auteur]
CIC - CHU Bichat
Laboratoire de Recherche Vasculaire Translationnelle [LVTS (UMR_S_1148 / U1148)]
Benhamou, Ygal [Auteur]
CHU Rouen
Alijotas-Reig, Jaume [Auteur]
Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona [UAB]
Vall d'Hebron University Hospital [Barcelona]
Fain, Olivier [Auteur]
Sorbonne Université - Faculté de Médecine [SU FM]
CHU Saint-Antoine [AP-HP]
Mékinian, Arsène [Auteur]
Sorbonne Université [SU]
CHU Saint-Antoine [AP-HP]

Journal title :

RMD Open : Rheumatic & Musculoskeletal Diseases

Pages :

e001340

Publisher :

BMJ

Publication date :

2020-08-26

ISSN :

2056-5933

English keyword(s) :

Antibodies
Antiphospholipid
Antiphospholipid Syndrome
Health Care
Outcome and Process Assessment

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective: To compare characteristics, pregnancies and treatments during pregnancies of seronegative and seropositive antiphospholipid syndrome (APS), to analyse factors associated with obstetrical outcome.Patients and ...
Show more >Objective: To compare characteristics, pregnancies and treatments during pregnancies of seronegative and seropositive antiphospholipid syndrome (APS), to analyse factors associated with obstetrical outcome.Patients and methods: Inclusion criteria were: (1) thrombotic and/or obstetrical APS (Sydney criteria); (2) absence of conventional antiphospholipid antibodies (APL); (3) at least one persistent non-conventional APL among IgA anticardiolipin antibodies, IgA anti-B2GPI, anti-vimentin G/M, anti-annexin V G/M, anti-phosphatidylethanolamine G/M and anti-phosphatidylserine/prothrombin G/M antibodies. The exclusion criteria were: (1) systemic lupus erythematosus ( SLE) or SLE-like disease; and (2) other connective tissue disease.Results: A total of 187 women (mean 33±5 years) with seronegative APS were included from 14 centres in Austria, Spain, Italy, Slovenia and France and compared with 285 patients with seropositive APS. Seronegative APS has more obstetrical rather than thrombotic phenotypes, with only 6% of venous thrombosis in comparison to seropositive APS. Cumulative incidence of adverse obstetrical events was similar in seronegative and seropositive APS patients, although higher rates of intrauterine deaths (15% vs 5%; p=0.03), of preeclampsia (7% vs 16%, p=0.048) and lower live birth term (36±3 vs 38±3 weeks of gestation; p=0.04) were noted in seropositive APS. The cumulative incidence of adverse obstetrical events was significantly improved in treated versus untreated seronegative APS (log rank<0.05), whereas there was no difference between patients who received aspirin or aspirin-low-molecular weighted heparin combination.Conclusion: Several non-criteria APL can be detected in patients with clinical APS features without any conventional APL, with various rates. The detection of non-criteria APL and thus the diagnosis of seronegative APS could discuss the therapeutic management similar to seropositive APS, but well-designed controlled studies are necessary.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167

Source :

Harvested from HAL