Title :

A smooth tubercle bacillus from Ethiopia phylogenetically close to the Mycobacterium tuberculosis complex

Author(s) :

Yenew, Bazezew [Auteur]
Ghodousi, Arash [Auteur]
Diriba, Getu [Auteur]
Tesfaye, Ephrem [Auteur]
Cabibbe, Andrea Maurizio [Auteur]
Amare, Misikir [Auteur]
Moga, Shewki [Auteur]
Alemu, Ayinalem [Auteur]
Dagne, Binyam [Auteur]
Sinshaw, Waganeh [Auteur]
Mollalign, Hilina [Auteur]
Meaza, Abyot [Auteur]
Tadesse, Mengistu [Auteur]
Gamtesa, Dinka Fikadu [Auteur]
Abebaw, Yeshiwork [Auteur]
Seid, Getachew [Auteur]
Zerihun, Betselot [Auteur]
Getu, Melak [Auteur]
Chiacchiaretta, Matteo [Auteur]
Gaudin, Cyril [Auteur]
Marceau, Michael [Auteur]
Didelot, Xavier [Auteur]
Tolera, Getachew [Auteur]
Abdella, Saro [Auteur]
Kebede, Abebaw [Auteur]
Getahun, Muluwork [Auteur]
Mehammed, Zemedu [Auteur]
Supply, Philip [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Cirillo, Daniela Maria [Auteur]

Journal title :

Nature Communications

Pages :

7519

Publisher :

Nature Publishing Group

Publication date :

2023-11-18

ISSN :

2041-1723

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Abstract The Mycobacterium tuberculosis complex (MTBC) includes several human- and animal-adapted pathogens. It is thought to have originated in East Africa from a recombinogenic Mycobacterium canettii -like ancestral pool. ...
Show more >Abstract The Mycobacterium tuberculosis complex (MTBC) includes several human- and animal-adapted pathogens. It is thought to have originated in East Africa from a recombinogenic Mycobacterium canettii -like ancestral pool. Here, we describe the discovery of a clinical tuberculosis strain isolated in Ethiopia that shares archetypal phenotypic and genomic features of M. canettii strains, but represents a phylogenetic branch much closer to the MTBC clade than to the M. canettii strains. Analysis of genomic traces of horizontal gene transfer in this isolate and previously identified M. canettii strains indicates a persistent albeit decreased recombinogenic lifestyle near the emergence of the MTBC. Our findings support that the MTBC emergence from its putative free-living M. canettii -like progenitor is evolutionarily very recent, and suggest the existence of a continuum of further extant derivatives from ancestral stages, close to the root of the MTBC, along the Great Rift Valley.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL