Title :

Hemodynamic and neuromuscular basis of reduced exercise capacity in patients with end-stage renal disease.

Author(s) :

Machfer, Amal [Auteur]
Université de Sfax
Tagougui, Sémah [Auteur]
Institut de Recherches Cliniques de Montréal [IRCM]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Zghal, Firas [Auteur]
Université de Sfax - University of Sfax
Ingénierie, Recherche et Intervention, Sport Santé et Environnement [IRISSE]
Hassen, Hayfa Ben Haj [Auteur]
Université de Sfax
Fekih, Nadia [Auteur]
Université de Sfax
Amor, Hassen Ibn Hadj [Auteur]
Chtourou, Hamdi [Auteur]
University of Tunis El Manar
Bouzid, Mohamed Amine [Auteur]
Université de Sfax

Journal title :

European Journal of Applied Physiology

Abbreviated title :

Eur J Appl Physiol

Publication date :

2024-02-22

ISSN :

1439-6327

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Purpose The present study aimed to characterize the exercise-induced neuromuscular fatigue and its possible links with cerebral and muscular oxygen supply and utilization to provide mechanistic insights into the reduced ...
Show more >Purpose The present study aimed to characterize the exercise-induced neuromuscular fatigue and its possible links with cerebral and muscular oxygen supply and utilization to provide mechanistic insights into the reduced exercise capacity characterizing patients with end-stage renal disease (ESRD). Methods Thirteen patients with ESRD and thirteen healthy males (CTR group) performed a constant-force sustained isometric contraction at 50% of their maximal voluntary isometric contraction (MVC) until exhaustion. Quadriceps muscle activation during exercise was estimated from vastus lateralis, vastus medialis, and rectus femoris EMG. Central and peripheral fatigue were quantified via changes in pre- to postexercise quadriceps voluntary activation (ΔVA) and quadriceps twitch force (ΔQtw,pot) evoked by supramaximal electrical stimulation, respectively. To assess cerebral and muscular oxygenation, throughout exercise, near-infrared spectroscopy allowed investigation of changes in oxyhemoglobin (∆O2Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the prefrontal cortex and in the vastus lateralis muscle. Results ESRD patients demonstrated lower exercise time to exhaustion than that of CTR (88.8 ± 15.3 s and 119.9 ± 14.6 s, respectively, P < 0.01). Following the exercise, MVC, Qtw,pot, and VA reduction were similar between the groups (P > 0.05). There was no significant difference in muscle oxygenation (∆O2Hb) between the two groups (P > 0.05). Cerebral and muscular blood volume (∆THb) and oxygen extraction (∆HHb) were significantly blunted in the ESRD group (P < 0.05). A significant positive correlation was observed between time to exhaustion and cerebral blood volume (∆THb) in both groups (r2 = 0.64, P < 0.01). Conclusions These findings support cerebral hypoperfusion as a factor contributing to the reduction in exercise capacity characterizing ESRD patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Submission date :

2024-02-23T22:09:11Z
2024-03-13T15:08:06Z