Colon targeting in rats, dogs and IBD patients with species-independent film coatings

Ferraro, Fabiana; Sonnleitner, Lisa; Neut, Christel; Mahieux, Séverine; Verin, Jérémy; Siepmann, Juergen; Siepmann, Florence

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.ijpx.2024.100233

PMID :

38379554

Permalink :

http://hdl.handle.net/20.500.12210/109327

Title :

Colon targeting in rats, dogs and IBD patients with species-independent film coatings

Author(s) :

Ferraro, Fabiana [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Sonnleitner, Lisa [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Neut, Christel [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Mahieux, Séverine [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Verin, Jérémy [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]

Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Florence [Auteur]

Advanced Drug Delivery Systems (ADDS) - U1008

Journal title :

International Journal of Pharmaceutics: X

Abbreviated title :

Int J Pharm X

Volume number :

Pages :

100233

Publication date :

2024-02-25

ISSN :

2590-1567

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Polysaccharides were identified, which allow for colon targeting in human Inflammatory Bowel Disease (IBD) patients, as well as in rats and dogs (which are frequently used as animals in preclinical studies). The polysaccharides ...
Show more >Polysaccharides were identified, which allow for colon targeting in human Inflammatory Bowel Disease (IBD) patients, as well as in rats and dogs (which are frequently used as animals in preclinical studies). The polysaccharides are degraded by colonic enzymes (secreted by bacteria), triggering the onset of drug release at the target site. It has to be pointed out that the microbiota in rats, dogs and humans substantially differ. Thus, the performance of this type of colon targeting system observed in animals might not be predictive for patients. The aim of this study was to limit this risk. Different polysaccharides were exposed to culture medium inoculated with fecal samples from IBD patients, healthy dogs and “IBD rats” (in which colonic inflammation was induced). Dynamic changes in the pH of the culture medium were used as an indicator for the proliferation of the bacteria and, thus, the potential of the polysaccharides to serve as their substrate. Fundamental differences were observed with respect to the extent of the pH variations as well as their species-dependency. The most promising polysaccharides were used to prepare polymeric film coatings surrounding 5-aminosaliciylic acid (5-ASA)-loaded starter cores. To limit premature polysaccharide dissolution/swelling in the upper gastro intestinal tract, ethylcellulose was also included in the film coatings. Drug release was monitored upon exposure to culture medium inoculated with fecal samples from IBD patients, healthy dogs and “IBD rats”. For reasons of comparison, also 5-ASA release in pure culture medium was measured. Most film coatings showed highly species-dependent drug release kinetics or limited colon targeting capacity. Interestingly, extracts from aloe vera and reishi (a mushroom) showed a promising potential for colon targeting in all species.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Submission date :

2024-02-26T22:00:31Z
2024-03-14T09:45:08Z

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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Colon targeting in rats, dogs and IBD ...

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