Title :

Possibility of dopant morphology control in the process of polymer impregnation with pharmaceuticals in a supercritical CO2 medium

Author(s) :

Oparin, Roman D. [Auteur]
Vaksler, Yevhenii [Auteur]
Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 [LASIRE]
Krestyaninov, Michael A. [Auteur]
Idrissi, Nacer [Auteur]
Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement (LASIRE) - UMR 8516
Kiselev, M. G. [Auteur]

Journal title :

Journal of Molecular Liquids

Abbreviated title :

J. Mol. Liq.

Volume number :

330

Pages :

-

Publication date :

2021-05-24

ISSN :

0167-7322

English keyword(s) :

Carbamazepine
Polymethylmethacrylate
Supercritical fluid technologies
Pharmaceuticals
Polymer matrix
Impregnation

HAL domain(s) :

Chimie/Chimie théorique et/ou physique

English abstract : [en]

In this paper we present the results of polymethylmethacrylate (PMMA) impregnation with carbamazepine (CBZ) in a supercritical carbon dioxide (scCO2) medium at two different temperatures (75 °C and 105 °C) at a constant ...
Show more >In this paper we present the results of polymethylmethacrylate (PMMA) impregnation with carbamazepine (CBZ) in a supercritical carbon dioxide (scCO2) medium at two different temperatures (75 °C and 105 °C) at a constant CO2 density. The obtained impregnated PMMA samples were analyzed by PXRD and Raman spectroscopy techniques. We have found that, irrespective of the impregnation process temperature, CBZ entrapped in the polymer matrix does not crystallize there but a CBZ solution in the PMMA is formed instead. It has been found that the CBZ concentration in the PMMA matrix grows as the impregnation process temperature rises due to the increase in the CBZ equilibrium concentration in the scCO2 phase, at that the conformational state of the CBZ molecules in the PMMA matrix was also found to depend on the impregnation process temperature. Finally, we showed that depending on the impregnation process temperature it is possible to obtain a PMMA matrix with either an opened or a sealed porous structure. In the latter case, not only CBZ, but also CO2 can be entrapped, remaining in the PMMA matrix in the high-density fluid state.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS

Collections :

• Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement (LASIRE) - UMR 8516

Submission date :

2024-02-28T23:30:33Z
2024-03-18T11:38:28Z