Titre :

Relationship between COVID-19 and ICU-Acquired Bloodstream Infections Related to Multidrug-Resistant Bacteria

Auteur(s) :

Piantoni, Antoine [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Houard, Marion [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Piga, Gaetan [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Zebian, Ghadi [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Ruffier Des Aimes, Sarah [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Holik, Bérénice [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Wallet, Frederic [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Rouze, Anahita [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Kreitmann, Louis [Auteur]
Hammersmith Hospital NHS Imperial College Healthcare
Imperial College London
Loiez, Caroline [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Labreuche, Julien [Auteur]
Service de Biostatistiques [CHRU Lille]
Nseir, Saad [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]

Titre de la revue :

Antibiotics (Basel, Switzerland)

Nom court de la revue :

Antibiotics

Numéro :

12

Pagination :

1105

Éditeur :

MDPI

Date de publication :

2023-06-25

ISSN :

2079-6382

Mot(s)-clé(s) en anglais :

SARS-CoV-2
COVID-19
bloodstream infection
ICU
multidrug-resistant bacteria
critical illness

Discipline(s) HAL :

Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique

Résumé en anglais : [en]

A bloodstream infection (BSI) is a severe ICU-acquired infection. A growing proportion is caused by multidrug-resistant bacteria (MDRB). COVID-19 was reported to be associated with a high rate of secondary infections. ...
Lire la suite >A bloodstream infection (BSI) is a severe ICU-acquired infection. A growing proportion is caused by multidrug-resistant bacteria (MDRB). COVID-19 was reported to be associated with a high rate of secondary infections. However, there is a lack of data on the relationship between COVID-19 and the incidence of MDRB ICU-acquired BSI. The aim of this study was to evaluate the relationship between COVID-19 and ICU-acquired BSI related to MDRB. This retrospective study was conducted in a single-center ICU during a one-year period. All adult patients admitted for more than 48 h were included. The cumulative incidence of ICU-acquired BSI related to MDRB was estimated using the Kalbfleisch and Prentice method. The association of COVID-19 status with the risk of ICU-acquired BSI related to MDRB was assessed using cause-specific Cox’s proportional hazard model. Among the 1320 patients included in the analysis, 497 (37.65%) had COVID-19. ICU-acquired BSI related to MDRB occurred in 50 patients (36 COVID patients (7%) and 14 non-COVID patients (1.6%)). Extended-spectrum beta-lactamase Enterobacteriacae (46%) and carbapenem-resistant Acinetobacter baumannii (30%) were the most commonly isolated MDRB. COVID-19 was significantly associated with a higher risk of MDRB ICU-acquired BSI (adjusted cHR 2.65 (1.25 to 5.59) for the whole study period). However, this relationship was only significant for the period starting at day 15 after ICU admission. ICU-acquired BSI related to MDRB was significantly associated with ICU mortality (HR (95%CI) 1.73 (1–3)), although COVID-19 had no significant impact on this association (p het 0.94). COVID-19 is significantly associated with an increased risk of ICU-acquired BSI related to MDRB, mainly during the period starting at day 15 after ICU admission.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Glycobiology in fungal Pathogenesis and Clinical Applications

Date de dépôt :

2024-03-01T10:53:04Z
2024-03-01T11:59:53Z