Liver Transplantation in Alcohol-related Liver Disease and Alcohol-related Hepatitis.

Ntandja Wandji, Line-Carolle; Ningarhari, Massih; Lassailly, Guillaume; Dharancy, Sebastien; Boleslawski, Emmanuel; Mathurin, Philippe; Louvet, Alexandre

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1016/j.jceh.2022.06.013

PMID :

36647412

Title :

Liver Transplantation in Alcohol-related Liver Disease and Alcohol-related Hepatitis.

Author(s) :

Ntandja Wandji, Line-Carolle [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Ningarhari, Massih [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Lassailly, Guillaume [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Dharancy, Sebastien [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Boleslawski, Emmanuel [Auteur]

Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Mathurin, Philippe [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Louvet, Alexandre [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Journal of Clinical and Experimental Hepatology

Pages :

127-138

Publication date :

2023-01-18

ISSN :

0973-6883

English keyword(s) :

alcohol
alcohol-related liver disease
alcohol-related hepatitis
liver transplantation
survival

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Alcohol-related liver disease (ARLD) remains one of the leading causes of chronic liver disease and the prevalence of alcohol-related cirrhosis is still increasing worldwide. Thus, ARLD is one of the leading indications ...
Show more >Alcohol-related liver disease (ARLD) remains one of the leading causes of chronic liver disease and the prevalence of alcohol-related cirrhosis is still increasing worldwide. Thus, ARLD is one of the leading indications for liver transplantation (LT) worldwide especially after the arrival of direct-acting antivirals for chronic hepatitis C infection. Despite the risk of alcohol relapse, the outcomes of LT for ARLD are as good as for other indications such as hepatocellular carcinoma (HCC), with 1-, 5-, and 10- year survival rates of 85%, 74%, and 59%, respectively. Despite these good results, certain questions concerning LT for ARLD remain unanswered, in particular because of persistent organ shortages. As a result, too many transplantation centers continue to require 6 months of abstinence from alcohol for patients with ARLD before LT to reduce the risk of alcohol relapse even though compelling data show the poor prognostic value of this criterion. A recent pilot study even observed a lower alcohol relapse rate in patients receiving LT after less than 6 months of abstinence as long as addictological follow-up is reinforced. Thus, the question should not be whether LT should be offered to patients with ARLD but how to select patients who will benefit from this treatment.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Source :

Harvested from HAL

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