Title :

Tristetraprolin expression by keratinocytes controls local and systemic inflammation

Author(s) :

Andrianne, Mathieu [Auteur]
Université libre de Bruxelles [ULB]
Walloon Excellence in Life sciences and BIOtechnology [Liège] [WELBIO]
Assabban, Assiya [Auteur]
Université libre de Bruxelles [ULB]
Walloon Excellence in Life sciences and BIOtechnology [Liège] [WELBIO]
La, Caroline [Auteur]
Université libre de Bruxelles [ULB]
Walloon Excellence in Life sciences and BIOtechnology [Liège] [WELBIO]
Mogilenko, Denis [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Salle, Delphine Staumont [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Fleury, Sébastien [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Doumont, Gilles [Auteur]
Université libre de Bruxelles [ULB]
van Simaeys, Gaëtan [Auteur]
Université libre de Bruxelles [ULB]
Nedospasov, Sergei [Auteur]
Lomonosov Moscow State University = Université d'État Lomonossov de Moscou [Moscou] [MSU]
Engelhardt Institute of Molecular Biology [ISTC]
Dombrowicz, David [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Blackshear, Perry [Auteur]
Duke University Medical Center
National Institute of Environmental Health Sciences [Durham, NC, USA] [NIEHS-NIH]
Goriely, Stanislas [Auteur]
Université libre de Bruxelles [ULB]
Walloon Excellence in Life sciences and BIOtechnology [Liège] [WELBIO]
Van Maele, Laurye [Auteur]
Université libre de Bruxelles [ULB]
Walloon Excellence in Life sciences and BIOtechnology [Liège] [WELBIO]

Journal title :

JCI Insight

Pages :

e92979

Publisher :

American Society for Clinical Investigation

Publication date :

2017-06-02

ISSN :

2379-3708

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates the mRNA stability of several important cytokines. Due to the critical role of this RNA-binding protein in the control of inflammation, TTP deficiency leads to the ...
Show more >Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates the mRNA stability of several important cytokines. Due to the critical role of this RNA-binding protein in the control of inflammation, TTP deficiency leads to the spontaneous development of a complex inflammatory syndrome. So far, this phenotype has been largely attributed to dysregulated production of TNF and IL‑23 by myeloid cells, such as macrophages or DCs. Here, we generated mice with conditional deletion of TTP in keratinocytes (Zfp36fl/flK14-Cre mice, referred to herein as Zfp36ΔEP mice). Unlike DC-restricted (CD11c-Cre) or myeloid cell-restricted (LysM-Cre) TTP ablation, these mice developed exacerbated inflammation in the imiquimod-induced psoriasis model. Furthermore, Zfp36ΔEP mice progressively developed a spontaneous pathology with systemic inflammation, psoriatic-like skin lesions, and dactylitis. Finally, we provide evidence that keratinocyte-derived TNF production drives these different pathological features. In summary, these findings expand current views on the initiation of psoriasis and related arthritis by revealing the keratinocyte-intrinsic role of TTP.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

EGID Diabetes Pole

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL