Titre :

Enhanced osteointegration of the ligament through a tailored local osteoinductive product delivery

Auteur(s) :

Zobrist, Cedric [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Chai, Feng [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Hamidi, Salim [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Daoudi, Mehdi [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Degoutin, Stephanie [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Titre de la manifestation scientifique :

ESB2022 - the 32nd Annual Conference of the European Society for Biomaterials

Ville :

Bordeaux

Pays :

France

Date de début de la manifestation scientifique :

2022-09

Discipline(s) HAL :

Chimie/Matériaux

Résumé en anglais : [en]

Tear of the Anterior Cruciate Ligament (ACL) is one of the most common knee injuries, which lead frequently to a surgery for recovery, due to the poor capacity of self-healing of the ligament1. The standard ACL reconstruction ...
Lire la suite >Tear of the Anterior Cruciate Ligament (ACL) is one of the most common knee injuries, which lead frequently to a surgery for recovery, due to the poor capacity of self-healing of the ligament1. The standard ACL reconstruction (ACLR) procedure uses an auto- or allograft harvested from the hamstring or patellar tendon. An alternative is to do the ACLR with a synthetic graft, which is introduced during the surgery through tunnels drilled in the tibial and the femoral bone to reproduce the natural anchoring of the ligament2. Although those ligaments provide high biomechanical properties, their poor biocompatibility can cause the widening of the bone tunnels due to a loose connection between the new ligament and the bone3. Hence, the solution we propose here is modify the ends of the artificial ligament with a core-sheath structure including a core braid loaded with bioactive glass (BG) and an overbraid with a windowed pattern that prevent the leak of bioactive glass and allow the osteoinduction through. This structure is designed to induce an optimal anchoring of the ligament in the neobone formed inside and outside the core-sheath ligament. The first goal of this study was to ensure the reliability of the protocol of BG incorporation to the device. The second goal was to induce biomineralization and to evaluate different sheath braid patterns to see how they allow the external growth throughout the windowed structure. Furthermore, we will also evaluate the cytotoxicity towards osteoblast cells.Lire moins >

Langue :

Anglais

Comité de lecture :

Non

Audience :

Internationale

Vulgarisation :

Non

Projet Européen :

European Regional Development Fund (FEDER)

Établissement(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Ingénierie des Systèmes Polymères

Date de dépôt :

2024-03-12T09:39:55Z
2024-03-12T10:12:08Z