The Polycomb Orthologues in Teleost Fishes and Their Expression in the Zebrafish Model

Raby, Ludivine; Völkel, Pamela; Le Bourhis, Xuefen; Angrand, Pierre-Olivier

Document type :

Article dans une revue scientifique: Article original

DOI :

10.3390/genes11040362

Title :

The Polycomb Orthologues in Teleost Fishes and Their Expression in the Zebrafish Model

Author(s) :

Raby, Ludivine [Auteur]
Völkel, Pamela [Auteur]
Le Bourhis, Xuefen [Auteur]
Angrand, Pierre-Olivier [Auteur correspondant]
Université de Lille
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]

Journal title :

Genes

Pages :

362

Publisher :

MDPI

Publication date :

2020-03-27

ISSN :

2073-4425

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The Polycomb Repressive Complex 1 (PRC1) is a chromatin-associated protein complex involved in transcriptional repression of hundreds of genes controlling development and differentiation processes, but also involved in ...
Show more >The Polycomb Repressive Complex 1 (PRC1) is a chromatin-associated protein complex involved in transcriptional repression of hundreds of genes controlling development and differentiation processes, but also involved in cancer and stem cell biology. Within the canonical PRC1, members of Pc/CBX protein family are responsible for the targeting of the complex to specific gene loci. In mammals, the Pc/CBX protein family is composed of five members generating, through mutual exclusion, different PRC1 complexes with potentially distinct cellular functions. Here, we performed a global analysis of the cbx gene family in 68 teleost species and traced the distribution of the cbx genes through teleost evolution in six fish super-orders. We showed that after the teleost-specific whole genome duplication, cbx4, cbx7 and cbx8 are retained as pairs of ohnologues. In contrast, cbx2 and cbx6 are present as pairs of ohnologues in the genome of several teleost clades but as singletons in others. Furthermore, since zebrafish is a widely used vertebrate model for studying development, we report on the expression of the cbx family members during zebrafish development and in adult tissues. We showed that all cbx genes are ubiquitously expressed with some variations during early development.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :