The Two-Way Relationship Between Calcium and Metabolism in Cancer

Dejos, Camille; Gkika, Dimitra; Cantelmo, Anna Rita

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.3389/fcell.2020.573747

Titre :

The Two-Way Relationship Between Calcium and Metabolism in Cancer

Auteur(s) :

Dejos, Camille [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Université de Lille
Gkika, Dimitra [Auteur]

Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Université de Lille
Cantelmo, Anna Rita [Auteur]

Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Université de Lille

Titre de la revue :

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Pagination :

573747

Éditeur :

Frontiers media

Date de publication :

2020-11-13

ISSN :

2296-634X

Mot(s)-clé(s) en anglais :

calcium
signaling
metabolism
interplay
cancer

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Calcium ion (Ca2+) signaling is critical to many physiological processes, and its kinetics and subcellular localization are tightly regulated in all cell types. All Ca2+ flux perturbations impact cell function and may ...
Lire la suite >Calcium ion (Ca2+) signaling is critical to many physiological processes, and its kinetics and subcellular localization are tightly regulated in all cell types. All Ca2+ flux perturbations impact cell function and may contribute to various diseases, including cancer. Several modulators of Ca2+ signaling are attractive pharmacological targets due to their accessibility at the plasma membrane. Despite this, the number of specific inhibitors is still limited, and to date there are no anticancer drugs in the clinic that target Ca2+ signaling. Ca2+ dynamics are impacted, in part, by modifications of cellular metabolic pathways. Conversely, it is well established that Ca2+ regulates cellular bioenergetics by allosterically activating key metabolic enzymes and metabolite shuttles or indirectly by modulating signaling cascades. A coordinated interplay between Ca2+ and metabolism is essential in maintaining cellular homeostasis. In this review, we provide a snapshot of the reciprocal interaction between Ca2+ and metabolism and discuss the potential consequences of this interplay in cancer cells. We highlight the contribution of Ca2+ to the metabolic reprogramming observed in cancer. We also describe how the metabolic adaptation of cancer cells influences this crosstalk to regulate protumorigenic signaling pathways. We suggest that the dual targeting of these processes might provide unprecedented opportunities for anticancer strategies. Interestingly, promising evidence for the synergistic effects of antimetabolites and Ca2+-modulating agents is emerging.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Projet ANR :

ULNE

Collections :