Opioid effect on the autonomic nervous system in a fetal sheep model

Recher, Morgan; Garabedian, Charles; Aubry, Estelle; Sharma, Dyuti; Madjid, Laura; Storme, Laurent; De Jonckheere, Julien

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1007/s00404-020-05917-4

PMID :

33389095

Title :

Opioid effect on the autonomic nervous system in a fetal sheep model

Author(s) :

Recher, Morgan [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Garabedian, Charles [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Aubry, Estelle [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Sharma, Dyuti [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Madjid, Laura [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Storme, Laurent [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
De Jonckheere, Julien [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]

Journal title :

Archives of Gynecology and Obstetrics

Pages :

p. 73–80

Publisher :

Springer Verlag

Publication date :

2021-01-01

ISSN :

0932-0067

English keyword(s) :

Autonomic nervous system
Fetal heart rate
Fetal sheep
Nalbuphine
Opioid

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

PurposeOpioid use during labour can interfere with cardiotocography patterns. Heart rate variability indirectly reflects a fluctuation in the autonomic nervous system and can be monitored through time and spectral analyses. ...
Show more >PurposeOpioid use during labour can interfere with cardiotocography patterns. Heart rate variability indirectly reflects a fluctuation in the autonomic nervous system and can be monitored through time and spectral analyses. This experimental study aimed to evaluate the impact of nalbuphine administration on the gasometric, cardiovascular, and autonomic nervous system responses in fetal sheep.MethodsThis was an experimental study on chronically instrumented sheep fetuses (surgery at 128 ± 2 days of gestational age, term = 145 days). The model was based on a maternal intravenous bolus injection of nalbuphine, a semisynthetic opioid used as an analgesic during delivery. Fetal gasometric parameters (pH, pO2, pCO2, and lactates), hemodynamic parameters (fetal heart rate and mean arterial pressure), and autonomic nervous system tone (short-term and long-term variation, low-frequency domain, high-frequency domain, and fetal stress index) were recorded. Data obtained at 30–60 min after nalbuphine injection were compared to those recorded at baseline.ResultsEleven experiments were performed. Fetal heart rate, mean arterial pressure, and activities at low and high frequencies were stable after injection. Short-term variation decreased at T30 min (P = 0.02), and long-term variation decreased at T60 min (P = 0.02). Fetal stress index gradually increased and reached significance at T60 min (P = 0.02). Fetal gasometric parameters and lactate levels remained stable.ConclusionMaternal nalbuphine use during labour may lead to fetal heart changes that are caused by the effect of opioid on the autonomic nervous system; these fluctuations do not reflect acidosis.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL

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