Title :

The role of the UPR pathway in response to treatment of gastroesophageal junction adenocarcinomas

Author(s) :

Degisors, Sébastien [Auteur]
Bourgery, Quentin [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Martin, Nathalie [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Brunin, Maxime [Auteur]
Marot, Guillemette [Auteur]
Renaud, Florence [Auteur]
Piessen, Guillaume [Auteur]
Wicquart, Laurence [Auteur]
Janas, Sylvie [Auteur]
Adenis, Antoine [Auteur]
Galmiche, Antoine [Auteur]
Pluquet, Olivier [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]

Conference title :

14th International Calreticulin Workshop

City :

Saint-Malo (France)

Country :

France

Start date of the conference :

2023-05-09

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Adenocarcinomas of the gastroesophageal junction (GEJ) represent 27% of all gastric tumors, are associated with a poor prognosis and their rate of recurrence remain very high. The molecular profiles of these adenocarcinomas ...
Show more >Adenocarcinomas of the gastroesophageal junction (GEJ) represent 27% of all gastric tumors, are associated with a poor prognosis and their rate of recurrence remain very high. The molecular profiles of these adenocarcinomas and the determinants of resistance to treatments are poorly known. In this study, our aim was to identify the UPR features associated with response to neoadjuvant chemotherapy in GEJ adenocarcinomas. By collecting pretreatment biopsy samples and post-treatment surgically resected tumor samples as well as healthy tissues, we showed that the expression of the UPR effector AGR2, a protein disulfide isomerase, may play a key role in response to chemotherapeutic drugs. Indeed, lower AGR2 expression was correlated with a better response to treatment. Our results on a GEJ adenocarcinoma cell line (OE19) indicated that (i) chemotherapies modulated the expression of UPR effectors; (ii) the inhibition of AGR2 by siRNA inhibited cell proliferation and increased cell death sensitization to chemotherapies; (iii) AGR2 knock-down affected the levels of UPR markers in response to treatments. Our data indicate that combination treatment of chemotherapy and selective inhibition of UPR component such as AGR2 may have beneficial effects for patients with GEJ adenocarcinomas.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL