Titre :

Fluorescent GD2 analog for single-molecule imaging

Auteur(s) :

Yamaguchi, Eriko [Auteur]
Gifu University
Komura, Naoko [Auteur]
Gifu University
Tanaka, Hide-Nori [Auteur]
Gifu University
Imamura, Akihiro [Auteur]
Gifu University
Ishida, Hideharu [Auteur]
Gifu University
Groux, Sophie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Mühlenhoff, Martina [Auteur]
Medizinische Hochschule Hannover = Hannover Medical School [MHH]
Suzuki, Kenichi G. N. [Auteur]
Gifu University
Ando, Hiromune [Auteur]
Gifu University

Titre de la revue :

Glycoconjugate Journal

Nom court de la revue :

Glycoconj J

Numéro :

40

Pagination :

247-257

Éditeur :

Springer Science and Business Media LLC

Date de publication :

2023-01-26

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes ...
Lire la suite >Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes (PMs), called lipid rafts, makes it difficult to observe. Previously, we developed fluorescent analogs of gangliosides (e.g., GM3 and GM1), which enabled the observation of lipid raft formation for the first time using single-molecule imaging. In this report, we describe the first chemical synthesis of a fluorescent ganglioside, GD2. A biophysical analysis of the synthesized analog revealed its raft-philic character, suggesting its potential to aid single-molecule imaging-based investigations into raft-associated interactions.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Régulation de la glycosylation terminale

Date de dépôt :

2024-03-22T13:18:08Z
2024-03-25T07:44:02Z