Title :

Fluorescent GD2 analog for single-molecule imaging

Author(s) :

Yamaguchi, Eriko [Auteur]
Gifu University
Komura, Naoko [Auteur]
Gifu University
Tanaka, Hide-Nori [Auteur]
Gifu University
Imamura, Akihiro [Auteur]
Gifu University
Ishida, Hideharu [Auteur]
Gifu University
Groux, Sophie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Mühlenhoff, Martina [Auteur]
Medizinische Hochschule Hannover = Hannover Medical School [MHH]
Suzuki, Kenichi G. N. [Auteur]
Gifu University
Ando, Hiromune [Auteur]
Gifu University

Journal title :

Glycoconjugate Journal

Abbreviated title :

Glycoconj J

Volume number :

40

Pages :

247-257

Publisher :

Springer Science and Business Media LLC

Publication date :

2023-01-26

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes ...
Show more >Ganglioside GD2 is associated with the proliferation and migration of breast cancer cells. However, the precise role of GD2 is unclear because its tendency to form dynamic and transient domains in cell plasma membranes (PMs), called lipid rafts, makes it difficult to observe. Previously, we developed fluorescent analogs of gangliosides (e.g., GM3 and GM1), which enabled the observation of lipid raft formation for the first time using single-molecule imaging. In this report, we describe the first chemical synthesis of a fluorescent ganglioside, GD2. A biophysical analysis of the synthesized analog revealed its raft-philic character, suggesting its potential to aid single-molecule imaging-based investigations into raft-associated interactions.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Régulation de la glycosylation terminale

Submission date :

2024-03-22T13:18:08Z
2024-03-25T07:44:02Z