Title :

Surgical Outcomes After Neoadjuvant Chemoradiation Followed by Curative Surgery in Patients With Esophageal Cancer

Author(s) :

von Holzen, Urs [Auteur]
Schmidt, Sven [Auteur]
Hayoz, Stefanie [Auteur]
Steffen, Thomas [Auteur]
Grieder, Felix [Auteur]
Bartsch, Detlef [Auteur]
Schnider, Annelies [Auteur]
Knoefel, Wolfram-Trudo [Auteur]
Piessen, Guillaume [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Kettelhack, Christoph [Auteur]
Marti, Walter [Auteur]
Schäfer, Markus [Auteur]
Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] [CHUV]
Függer, Reinhold [Auteur]
Köigsrainer, Alfred [Auteur]
Gloor, Beat [Auteur]
Furrer, Markus [Auteur]
Gérard, Marie-Aline [Auteur]
Architecture et Réactivité de l'ARN [ARN]
Hawle, Hanne [Auteur]
Walz, Martin [Auteur]
Kliniken Essen-Mitte
Alesina, Piero [Auteur]
Kliniken Essen-Mitte
Ruhstaller, Thomas [Auteur]

Journal title :

Annals of Surgery

Pages :

1130-1136

Publisher :

Lippincott, Williams & Wilkins

Publication date :

2022-06-26

ISSN :

0003-4932

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Objective: To assess the impact of surgical technique in regard to morbidity and mortality after neoadjuvant treatment for esophageal cancer. Background: The SAKK trial 75/08 was a multicenter phase III trial (NCT01107639) ...
Show more >Objective: To assess the impact of surgical technique in regard to morbidity and mortality after neoadjuvant treatment for esophageal cancer. Background: The SAKK trial 75/08 was a multicenter phase III trial (NCT01107639) comparing induction chemotherapy followed by chemoradiation and surgery in patients with locally advanced esophageal cancer. Methods: Patients in the control arm received induction chemotherapy with cisplatin and docetaxel, followed by concomitant chemoradiation therapy with cisplatin, docetaxel, and 45Gy. In the experimental arm, the same regimen was used with addition of cetuximab. After completion of neoadjuvant treatment, patients underwent esophagectomy. The experimental arm received adjuvant cetuximab. Surgical outcomes and complications were prospectively recorded and analyzed. Results: Total of 259 patients underwent esophagectomy. Overall complication rate was 56% and reoperation rate was 15% with no difference in complication rates for transthoracic versus transhiatal resections (56% vs 54%, P = 0.77), nor for video assisted thoracic surgeries (VATS) versus open transthoracic resections (67% vs 55%, P = 0.32). There was a trend to higher overall complication rates in squamous cell carcinoma versus adenocarcinoma (65% vs 51%, P = 0.035), and a significant difference in ARDS in squamous cell carcinoma with 14% versus 2% in adenocarcinoma ( P = 0.0002). For patients with involved lymph nodes, a lymph node ratio of ≥0.1 was an independent predictor of PFS (HR 2.5, P = 0.01) and OS (HR 2.2, P = 0.03). Conclusions: This trial showed no difference in surgical complication rates between transthoracic and transhiatal resections. For patients with involved lymph nodes, lymph node ratio was an independent predictor of progression free survival and overall survival.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL