Titre :

Delayed Surgical Intervention After Chemoradiotherapy in Esophageal Cancer

Auteur(s) :

Chidambaram, Swathikan [Auteur]
Owen, Richard [Auteur]
Sgromo, Bruno [Auteur]
Chmura, Magdalena [Auteur]
Kisiel, Aaron [Auteur]
Evans, Richard [Auteur]
University of Westminster [London] [UOW]
Griffiths, Ewen [Auteur]
Castoro, Carlo [Auteur]
Gronnier, Caroline [Auteur]
Hôpital Haut-Lévêque [CHU Bordeaux]
Maoawyes, Mometo Ali [Auteur]
Gutschow, Christian [Auteur]
Piessen, Guillaume [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Degisors, Sébastien [Auteur]
Alvieri, Rita [Auteur]
Feldman, Hope [Auteur]
Capovilla, Giovanni [Auteur]
Grimminger, Peter [Auteur]
Han, Shiwei [Auteur]
Low, Donald [Auteur]
Moore, Jonathan [Auteur]
University of Warwick [Coventry]
Gossage, James [Auteur]
Voeten, Dan [Auteur]
Gisbertz, Suzanne [Auteur]
Ruurda, Jelle [Auteur]
van Hillegersberg, Richard [Auteur]
D’journo, Xavier [Auteur]
Chmelo, Jakub [Auteur]
Phillips, Alexander [Auteur]
Rosati, Riccardo [Auteur]
Hanna, George [Auteur]
Maynard, Nick [Auteur]
Hofstetter, Wayne [Auteur]
Ferri, Lorenzo [Auteur]
Berge Henegouwen, Mark [Auteur]
Markar, Sheraz [Auteur]

Titre de la revue :

Annals of Surgery

Pagination :

701-708

Éditeur :

Lippincott, Williams & Wilkins

Date de publication :

2023-11-21

ISSN :

0003-4932

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Cancer

Résumé en anglais : [en]

Objective: To determine the impact of delayed surgical intervention following chemoradiotherapy (CRT) on survival from esophageal cancer. Background: CRT is a core component of multimodality treatment for locally advanced ...
Lire la suite >Objective: To determine the impact of delayed surgical intervention following chemoradiotherapy (CRT) on survival from esophageal cancer. Background: CRT is a core component of multimodality treatment for locally advanced esophageal cancer. The timing of surgery following CRT may influence the probability of performing an oncological resection and the associated operative morbidity. Methods: This was an international, multicenter, cohort study, including patients from 17 centers who received CRT followed by surgery between 2010 and 2020. In the main analysis, patients were divided into 4 groups based upon the interval between CRT and surgery (0–50, 51–100, 101–200, and >200 days) to assess the impact upon 90-day mortality and 5-year overall survival. Multivariable logistic and Cox regression provided hazard ratios (HRs) with 95% CIs adjusted for relevant patient, oncological, and pathologic confounding factors. Results: A total of 2867 patients who underwent esophagectomy after CRT were included. After adjustment for relevant confounders, prolonged interval following CRT was associated with an increased 90-day mortality compared with 0 to 50 days (reference): 51 to 100 days (HR=1.54, 95% CI: 1.04–2.29), 101 to 200 days (HR=2.14, 95% CI: 1.37–3.35), and >200 days (HR=3.06, 95% CI: 1.64–5.69). Similarly, a poorer 5-year overall survival was also observed with prolonged interval following CRT compared with 0 to 50 days (reference): 101 to 200 days (HR=1.41, 95% CI: 1.17–1.70), and >200 days (HR=1.64, 95% CI: 1.24–2.17). Conclusions: Prolonged interval following CRT before esophagectomy is associated with increased 90-day mortality and poorer long-term survival. Further investigation is needed to understand the mechanism that underpins these adverse outcomes observed with a prolonged interval to surgery.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL