Titre :

Clinical Features of Gastric Signet Ring Cell Cancer: Results from a Systematic Review and Meta-Analysis

Auteur(s) :

Dal Cero, Mariagiulia [Auteur]
Bencivenga, Maria [Auteur]
Liu, Drolaiz [Auteur]
Sacco, Michele [Auteur]
Alloggio, Mariella [Auteur]
Kerckhoffs, Kelly [Auteur]
Filippini, Federica [Auteur]
Dipartimento di Electtronica, Informazione e Bioingegneria [Politecnico Milano] [POLIMI]
Saragoni, Luca [Auteur]
Iglesias, Mar [Auteur]
Tomezzoli, Anna [Auteur]
Carneiro, Fátima [Auteur]
Universidade do Porto = University of Porto
Grabsch, Heike [Auteur]
Maastricht University Medical Centre [MUMC]
Verlato, Giuseppe [Auteur]
Torroni, Lorena [Auteur]
Piessen, Guillaume [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Pera, Manuel [Auteur]
de Manzoni, Giovanni [Auteur]

Titre de la revue :

Cancers

Pagination :

5191

Éditeur :

MDPI

Date de publication :

2023-10-28

ISSN :

2072-6694

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Cancer

Résumé en anglais : [en]

Background: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis ...
Lire la suite >Background: Conflicting results about the prognostic relevance of signet ring cell histology in gastric cancer have been reported. We aimed to perform a meta-analysis focusing on the clinicopathological features and prognosis of this subgroup of cancer compared with other histologies. Methods: A systematic literature search in the PubMed database was conducted, including all publications up to 1 October 2021. A meta-analysis comparing the results of the studies was performed. Results: A total of 2062 studies referring to gastric cancer with signet ring cell histology were identified, of which 262 studies reported on its relationship with clinical information. Of these, 74 were suitable to be included in the meta-analysis. A slightly lower risk of developing nodal metastases in signet ring cell tumours compared to other histotypes was found (especially to undifferentiated/poorly differentiated/mucinous and mixed histotypes); the lower risk was more evident in early and slightly increased in advanced gastric cancer. Survival tended to be better in early stage signet ring cell cancer compared to other histotypes; no differences were shown in advanced stages, and survival was poorer in metastatic patients. In the subgroup analysis, survival in signet ring cell cancer was slightly worse compared to non-signet ring cell cancer and differentiated/well-to-moderately differentiated adenocarcinoma. Conclusions: Most of the conflicting results in signet ring cell gastric cancer literature could be derived from the lack of standardisation in their classification and the comparison with the different subtypes of gastric cancer. There is a critical need to strive for a standardised classification system for gastric cancer, fostering clarity and coherence in the forthcoming research and clinical applications.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL