Porous Maltodextrin-Based Nanoparticles: ...
Document type :
Article dans une revue scientifique: Article original
DOI :
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Title :
Porous Maltodextrin-Based Nanoparticles: A Safe Delivery System for Nasal Vaccines
Author(s) :
Carpentier, Rodolphe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Platel, Anne [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Salah, Norhane [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Nesslany, Fabrice [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Betbeder, Didier [Auteur]
498252|||Lille Inflammation Research International Center - U 995 [LIRIC]
Université d'Artois [UA]

Lille Inflammation Research International Center - U 995 [LIRIC]
Platel, Anne [Auteur]

Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Salah, Norhane [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Nesslany, Fabrice [Auteur]

Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Betbeder, Didier [Auteur]

498252|||Lille Inflammation Research International Center - U 995 [LIRIC]
Université d'Artois [UA]
Journal title :
Journal of Nanomaterials
Abbreviated title :
J. Nanomater.
Volume number :
2018
Pages :
ID 9067195
Publisher :
Hindawi Publishing Corporation
Publication date :
2018-12-16
ISSN :
1687-4110
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Vaccination faces limitations, and delivery systems additionally appear to have potential as tools to trigger protective immune responses against diseases. The nanoparticles studied are cationic maltodextrin-based nanoparticles ...
Show more >Vaccination faces limitations, and delivery systems additionally appear to have potential as tools to trigger protective immune responses against diseases. The nanoparticles studied are cationic maltodextrin-based nanoparticles with an anionic phospholipid core (NPL); they are a promising antigen delivery system, and their efficacy as drug vectors against complex diseases such as toxoplasmosis has already been demonstrated. Cationic compounds are generally described as toxic; therefore, it is of interest to evaluate the behavior of these NPL in vitro and in vivo. Here, we studied the in vitro toxicity (cytotoxicity and ROS induction in intestinal and airway epithelial cell lines) and the in vivo tolerability and genotoxicity of these nanoparticles administered by the nasal route to a rodent model. In vitro, these NPL were not cytotoxic and did not induce any ROS production. In vivo, even at very large doses (1000 times the expected human dose), no adverse effect and no genotoxicity were observed in lungs, stomach, colon, or liver. This study shows that these NPL can be safely used.Show less >
Show more >Vaccination faces limitations, and delivery systems additionally appear to have potential as tools to trigger protective immune responses against diseases. The nanoparticles studied are cationic maltodextrin-based nanoparticles with an anionic phospholipid core (NPL); they are a promising antigen delivery system, and their efficacy as drug vectors against complex diseases such as toxoplasmosis has already been demonstrated. Cationic compounds are generally described as toxic; therefore, it is of interest to evaluate the behavior of these NPL in vitro and in vivo. Here, we studied the in vitro toxicity (cytotoxicity and ROS induction in intestinal and airway epithelial cell lines) and the in vivo tolerability and genotoxicity of these nanoparticles administered by the nasal route to a rodent model. In vitro, these NPL were not cytotoxic and did not induce any ROS production. In vivo, even at very large doses (1000 times the expected human dose), no adverse effect and no genotoxicity were observed in lungs, stomach, colon, or liver. This study shows that these NPL can be safely used.Show less >
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Institut Pasteur de Lille
Inserm
Université de Lille
Institut Pasteur de Lille
Collections :
Research team(s) :
Therapeutic innovation targetting inflammation
Submission date :
2019-05-17T13:08:37Z
2021-06-23T07:08:33Z
2022-11-21T15:37:56Z
2021-06-23T07:08:33Z
2022-11-21T15:37:56Z
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