Selective Pinacol-Coupling Reaction using ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
Permalink :
Title :
Selective Pinacol-Coupling Reaction using a Continuous Flow System
Author(s) :
Sotto, Nicolas [Auteur]
Cazorla, Clement [Auteur]
Villette, Carole [Auteur]
Billamboz, Muriel [Auteur]
Len, Christophe [Auteur]
Cazorla, Clement [Auteur]
Villette, Carole [Auteur]
Billamboz, Muriel [Auteur]
Len, Christophe [Auteur]
Journal title :
The Journal of organic chemistry
Abbreviated title :
J. Org. Chem.
Volume number :
81
Pages :
11065-11071
Publication date :
2016-11-18
ISSN :
0022-3263
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The first continuous flow pinacol coupling reaction of carbonyl compounds was successfully achieved within only 2 min during a single pass through a cartridge filled with zinc(0). The optimized method allowed the efficient ...
Show more >The first continuous flow pinacol coupling reaction of carbonyl compounds was successfully achieved within only 2 min during a single pass through a cartridge filled with zinc(0). The optimized method allowed the efficient production of gram-scale value-added compounds with high productivity. The developed methodology is efficient for aromatic or α,β-unsaturated aldehydes but gives moderate results for more stable acetophenone derivatives. Moreover, the flow method displayed better results in terms of yield and selectivity in comparison to the corresponding batch methodology.Show less >
Show more >The first continuous flow pinacol coupling reaction of carbonyl compounds was successfully achieved within only 2 min during a single pass through a cartridge filled with zinc(0). The optimized method allowed the efficient production of gram-scale value-added compounds with high productivity. The developed methodology is efficient for aromatic or α,β-unsaturated aldehydes but gives moderate results for more stable acetophenone derivatives. Moreover, the flow method displayed better results in terms of yield and selectivity in comparison to the corresponding batch methodology.Show less >
Audience :
Internationale
Popular science :
Non
Research team(s) :
Therapeutic innovation targetting inflammation
Submission date :
2019-05-17T13:08:37Z