Title :

Distinctly Different Dynamics and Kinetics of Two Steroid Receptors at the Same Response Elements in Living Cells

Author(s) :

Nenseth, Hatice Z. [Auteur]
Dezitter, Xavier [Auteur]
Tesikova, Martina [Auteur]
Mueller, Florian [Auteur]
Klokk, Tove I. [Auteur]
Hager, Gordon L. [Auteur]
Saatcioglu, Fahri [Auteur]

Journal title :

PLoS One

Abbreviated title :

PLoS One

Volume number :

9

Publication date :

2014-08-18

ISSN :

1932-6203

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Closely related transcription factors (TFs) can bind to the same response elements (REs) with similar affinities and activate transcription. However, it is unknown whether transcription is similarly orchestrated by different ...
Show more >Closely related transcription factors (TFs) can bind to the same response elements (REs) with similar affinities and activate transcription. However, it is unknown whether transcription is similarly orchestrated by different TFs bound at the same RE. Here we have compared the recovery half time (t1/2), binding site occupancy and the resulting temporal changes in transcription upon binding of two closely related steroid receptors, the androgen and glucocorticoid receptors (AR and GR), to their common hormone REs (HREs). We show that there are significant differences at all of these levels between AR and GR at the MMTV HRE when activated by their ligands. These data show that two TFs bound at the same RE can have significantly different modes of action that can affect their responses to environmental cues.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Therapeutic innovation targetting inflammation

Submission date :

2019-05-17T13:08:43Z