Title :

Factors of Early Recurrence After Resection for Intrahepatic Cholangiocarcinoma

Author(s) :

Nassar, Alexandra [Auteur]
CHU Saint-Antoine [AP-HP]
Tzedakis, Stylianos [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris]
Sindayigaya, Rémy [Auteur]
Fédération Hospitalo-universitaire SUrvival oPtimization in ORgan Transplantation [FHU SUPORT]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Hobeika, Christian [Auteur]
Université Paris Cité [UPCité]
Hôpital Beaujon [AP-HP]
Marchese, Ugo [Auteur]
Institut Paoli-Calmettes [IPC]
Veziant, Julie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Groupe francophone de Réhabilitation Améliorée après Chirurgie [GRACE]
Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Codjia, Tatiana [Auteur]
Service de Chirurgie Digestive [CHU Rouen]
Beaufrère, Aurélie [Auteur]
Dhote, Alix [Auteur]
Hôpital Cochin [AP-HP]
Strigalev, Marie [Auteur]
Cauchy, François [Auteur]
Université Paris Cité [UPCité]
Hôpital Beaujon [AP-HP]
Fuks, David [Auteur]
Hôpital Cochin [AP-HP]
Institut Cochin [IC UM3 (UMR 8104 / U1016)]

Journal title :

World journal of surgery

Pages :

2459-2467

Publisher :

Springer Verlag

Publication date :

2022-07-11

ISSN :

0364-2313

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

<b>Background</b></br>Two‐thirds of patients undergoing liver resection for intrahepatic cholangiocarcinoma experience recurrence after surgery. Our aim was to identify factors associated with early recurrence after resection ...
Show more ><b>Background</b></br>Two‐thirds of patients undergoing liver resection for intrahepatic cholangiocarcinoma experience recurrence after surgery. Our aim was to identify factors associated with early recurrence after resection for intrahepatic cholangiocarcinoma.</br><b>Methods</b></br>Patients with intrahepatic cholangiocarcinoma undergoing curative intent resection (complete resection and lymphadenectomy) were included in two centers between 2005 and 2021 and were divided into three groups: early recurrence (< 12 months after resection), delayed recurrence (> 12 months), and no recurrence. Patients experiencing early (< 90 days) postoperative mortality were excluded.</br><b>Results</b></br>Among 120 included patients, 44 (36.7%) experienced early recurrence, 24 (20.0%) experienced delayed recurrence, and 52 (43.3%) did not experience recurrence after a median follow‐up of 59 months (IQR: 26‐113). The median recurrence‐free survival was 16 months (95% CI: 9.6–22.4). Median overall survival was 55 months (95% CI: 45.7–64.3), while it was 25 months for patients with early recurrence ( p < 0.001). Patients with early recurrence had significantly larger tumors (59.1% of tumors > 70 mm in early vs. 58.3% in delayed vs. 26.9% in no recurrence group, p = 0.002), multiple lesions (65.9% vs. 29.2% vs. 11.5%, p < 0.001), and positive lymph nodes (N +) (38.6% vs. 37.5% vs. 11.5%, p = 0.005). In multivariable analysis, presence of multiple lesions (OR: 9.324; 95% CI: 3.051–28.489; p < 0.001) and positive lymph nodes (OR: 3.307. 95% CI: 1.001–11.011. p = 0.05) were associated with early recurrence.</br><b>Conclusion</b></br>Early recurrence after curative resection of intrahepatic cholangiocarcinoma is frequent and is associated with the presence of multiple lesions and positive lymph nodes, raising the question of surgery's futility in this context.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL