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Synthesis and biological evaluation of a ...
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Document type :
Article dans une revue scientifique
DOI :
10.1016/j.ejmech.2012.11.008
PMID :
23207411
Permalink :
http://hdl.handle.net/20.500.12210/11244
Title :
Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors
Author(s) :
Abuhaie, Cristina-Maria [Auteur]
Ghinet, Alina [Auteur] refId
Farce, Amaury [Auteur] refId
Dubois, Joelle [Auteur]
Gautret, Philippe [Auteur]
Rigo, Benoit [Auteur]
Belei, Dalila [Auteur]
Bicu, Elena [Auteur]
Journal title :
European journal of medicinal chemistry
Abbreviated title :
Eur. J. Med. Chem.
Volume number :
59
Pages :
101-110
Publication date :
2013-01-01
ISSN :
0223-5234
English keyword(s) :
Fanesyltransferase inhibitors
Ylide
Anticancer agent
Pyridin-(1H)-ylidene
Phenothiazine
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Two new families of human farnesyltransferase inhibitors 13a-m and 14a-d, based on a phenothiazine scaffold, were synthesized. Compounds 14a and 14b were the most promising inhibitors of human farnesyltransferase with ...
Show more >
Two new families of human farnesyltransferase inhibitors 13a-m and 14a-d, based on a phenothiazine scaffold, were synthesized. Compounds 14a and 14b were the most promising inhibitors of human farnesyltransferase with IC(50) values of 0.7 and 0.6 μM, respectively.Show less >
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Collections :
  • Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Research team(s) :
Therapeutic innovation targetting inflammation
Submission date :
2019-05-17T13:14:32Z
Université de Lille

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