Design and synthesis of fused tetrahydro ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines
Author(s) :
Moas-Heloire, Valeria [Auteur]
Renault, Nicolas [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lille Inflammation Research International Center - U 995 [LIRIC]
Batalha, Vania [Auteur]
Rincon, Arias Angela [Auteur]
Marchivie, Mathieu [Auteur]
Yous, Said [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Deguine, Noemie [Auteur]
Buee, Luc [Auteur]
Chavatte, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Blum, David [Auteur]
Lopes, Luisa [Auteur]
Melnyk, Patricia [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Agouridas, Laurence [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Renault, Nicolas [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lille Inflammation Research International Center - U 995 [LIRIC]
Batalha, Vania [Auteur]
Rincon, Arias Angela [Auteur]
Marchivie, Mathieu [Auteur]
Yous, Said [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Deguine, Noemie [Auteur]
Buee, Luc [Auteur]

Chavatte, Philippe [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Blum, David [Auteur]

Lopes, Luisa [Auteur]
Melnyk, Patricia [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Agouridas, Laurence [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Journal title :
European journal of medicinal chemistry
Abbreviated title :
Eur. J. Med. Chem.
Volume number :
106
Pages :
15-25
Publication date :
2015-12-01
ISSN :
0223-5234
English keyword(s) :
Privileged structure
Iminoimidazoline
Guanidines
A(2A) receptor
Iminoimidazoline
Guanidines
A(2A) receptor
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
In the aim of identifying new privileged structures, we describe the 5-steps synthesis of cyclic guanidine compounds "tetrahydroisoquinoline-iminoimidazolines" derived from tetrahydroisoquinoline-hydantoin core. In order ...
Show more >In the aim of identifying new privileged structures, we describe the 5-steps synthesis of cyclic guanidine compounds "tetrahydroisoquinoline-iminoimidazolines" derived from tetrahydroisoquinoline-hydantoin core. In order to evaluate this new minimal structure and the impact of replacing a carbonyle by a guanidine moiety, their affinity towards adenosine receptor A2A was evaluated and compared to those of tetrahydroisoquinoline-hydantoin compounds.Show less >
Show more >In the aim of identifying new privileged structures, we describe the 5-steps synthesis of cyclic guanidine compounds "tetrahydroisoquinoline-iminoimidazolines" derived from tetrahydroisoquinoline-hydantoin core. In order to evaluate this new minimal structure and the impact of replacing a carbonyle by a guanidine moiety, their affinity towards adenosine receptor A2A was evaluated and compared to those of tetrahydroisoquinoline-hydantoin compounds.Show less >
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Therapeutic innovation targetting inflammation
Submission date :
2019-05-17T13:14:37Z
2021-05-28T09:51:15Z
2021-05-28T09:51:15Z