Title :

Impact of the Polymer Dispersity on the Properties of Curcumin/Polyvinylpyrrolidone Amorphous Solid Dispersions

Author(s) :

Samsoen, Simon [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Dudognon, Emeline [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Le Fer, Gaëlle [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Fournier, David [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Woisel, Patrice [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Affouard, Frédéric [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

International Journal of Pharmaceutics

Volume number :

653

Pages :

123895

Publication date :

2024-03-25

English keyword(s) :

Amorphous solid dispersions
Curcumin
Polyvinylpyrrolidone
dispersity
glass-transition
solubility

HAL domain(s) :

Chimie

English abstract : [en]

Amorphous solid dispersions (ASD) are known to enhance the absorption of poorly water-soluble drugs. In this work we synthesise well-defined Polyvinylpyrrolidone (PVP) to establish the impact of dispersity and chain-end ...
Show more >Amorphous solid dispersions (ASD) are known to enhance the absorption of poorly water-soluble drugs. In this work we synthesise well-defined Polyvinylpyrrolidone (PVP) to establish the impact of dispersity and chain-end functionality on the physical properties of Curcumin (CUR)/PVP ASD. Thermodynamic characterisation of synthesised PVP emphasises a strong effect of the dispersity on the glass transition temperature (Tg), 50 °C higher for synthesised PVP than for commercial PVP K12 of same molar mass. This increase of Tg affects the thermodynamic properties of CUR/PVP ASD successfully formulated up to 70 wt.% of CUR by milling or solvent evaporation. The evolution of both the Tg and CUR solubility values versus CUR content points out the development of fairly strong CUR-PVP interactions that strengthen the antiplasticising effect of PVP on the Tg of ASD. However, for ASD formulated with commercial PVP this effect is counterbalanced at low CUR content by a plasticising effect due to the shortest PVP chains. Moreover, the overlay of the phase and state diagrams highlights the strong impact of the polymer dispersity on the stability of CUR/PVP ASD. ASD formulated with low dispersity PVP are stable on larger temperature and concentration ranges than those formulated with PVP K12.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Other project(s) or funding source(s) :

Interreg 2 Seas programme “Site Drug 2S07-033”

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques
Ingénierie des Systèmes Polymères

Submission date :

2024-04-08T15:15:20Z
2024-04-10T06:56:20Z