Title :

Synthetic parasites: a successful mucosal nanoparticle vaccine against Toxoplasma congenital infection in mice

Author(s) :

Ducournau, Celine [Auteur]
Nguyen, Thi Tl [Auteur]
Carpentier, Rodolphe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lantier, Isabelle [Auteur]
Germon, Stephanie [Auteur]
Precausta, Flavien [Auteur]
Pisella, Pierre-Jean [Auteur]
Leroux, Herve [Auteur]
Langendonck, Nathalie Van [Auteur]
Betbeder, Didier [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Dimier-Poisson, Isabelle [Auteur]

Journal title :

Future microbiology

Abbreviated title :

Future Microbiol.

Volume number :

12

Pages :

393-405

Publication date :

2017-04-01

ISSN :

1746-0913

English keyword(s) :

congenital toxoplasmosis
nasal vaccination
nanoparticles

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis.Mice ...
Show more >Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis.Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, parasitic load rates were studied.Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated.Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Therapeutic innovation targetting inflammation

Submission date :

2019-05-17T13:14:41Z