Design, synthesis and evaluation of 2-aryl ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor.
Author(s) :
Duroux, Romain [Auteur]
Renault, Nicolas [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Cuelho Joana, Esteves [Auteur]
Agouridas, Laurence [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Blum, David [Auteur]
Lopes, Luisa [Auteur]
Melnyk, Patricia [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Yous, Said [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Renault, Nicolas [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Cuelho Joana, Esteves [Auteur]
Agouridas, Laurence [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Blum, David [Auteur]
Lopes, Luisa [Auteur]
Melnyk, Patricia [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Yous, Said [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Journal title :
Journal of enzyme inhibition and medicinal chemistry
Abbreviated title :
J Enzyme Inhib Med Chem
Volume number :
32
Pages :
850-864
Publication date :
2017-12-01
ISSN :
1475-6374
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The development of adenosine A receptor antagonists has received much interest in recent years for the treatment of neurodegenerative diseases. Based on docking studies, a new series of 2-arylbenzoxazoles has been identified ...
Show more >The development of adenosine A receptor antagonists has received much interest in recent years for the treatment of neurodegenerative diseases. Based on docking studies, a new series of 2-arylbenzoxazoles has been identified as potential AR antagonists. Structure-affinity relationship was investigated in position 2, 5 and 6 of the benzoxazole heterocycle leading to compounds with a micromolar affinity towards the A receptor. Compound F1, with an affinity of 1 μm, presented good absorption, distribution, metabolism and excretion properties with an excellent aqueous solubility (184 μm) without being cytotoxic at 100 μm. This compound, along with low-molecular weight compound D1 (K = 10 μm), can be easily modulated and thus considered as relevant starting points for further hit-to-lead optimisation.Show less >
Show more >The development of adenosine A receptor antagonists has received much interest in recent years for the treatment of neurodegenerative diseases. Based on docking studies, a new series of 2-arylbenzoxazoles has been identified as potential AR antagonists. Structure-affinity relationship was investigated in position 2, 5 and 6 of the benzoxazole heterocycle leading to compounds with a micromolar affinity towards the A receptor. Compound F1, with an affinity of 1 μm, presented good absorption, distribution, metabolism and excretion properties with an excellent aqueous solubility (184 μm) without being cytotoxic at 100 μm. This compound, along with low-molecular weight compound D1 (K = 10 μm), can be easily modulated and thus considered as relevant starting points for further hit-to-lead optimisation.Show less >
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Therapeutic innovation targetting inflammation
Submission date :
2019-05-17T13:14:50Z
2021-05-28T09:52:01Z
2021-05-28T09:52:01Z