Title :

Antioxidant Activity of New Benzo[de]quinolines and Lactams: 2D-Quantitative Structure-Activity Relationships

Author(s) :

Ghinet, Alina [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Farce, Amaury [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Oudir, Souhila [Auteur]
Pommery, Jean [Auteur]
Vamecq, Joseph [Auteur]
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Henichart, Jean-Pierre [Auteur]
Rigo, Benoit [Auteur]
Gautret, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Medicinal chemistry (Shariqah (United Arab Emirates))

Abbreviated title :

J. Med. Chem.

Volume number :

8

Pages :

942-946

Publication date :

2012-09-01

ISSN :

1573-4064

English keyword(s) :

benzo[de]quinoline
antioxidant agent
2D-QSAR
Lactam
hydroxyketolactam

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

In order to predict the antioxidant activity of 7 polycyclic lactams, a two dimensional quantitative-structure activity relationships (2D-QSAR) study based on a 5-descriptor model was performed. The synthetic compounds ...
Show more >In order to predict the antioxidant activity of 7 polycyclic lactams, a two dimensional quantitative-structure activity relationships (2D-QSAR) study based on a 5-descriptor model was performed. The synthetic compounds built from a condensed lactam scaffold were screened for their abilities to inhibit the autoxidation of pyrogallol, a superoxide anion radical-dependent process. The ketone 2 (8,9-dihydro-7H-benzo[de]pyrrolo[1,2-a]quinoline-7,10(7aH)-dione) exhibited the most potent antioxidant activity in vitro. The oxidation mechanism was proved by the isolation and characterization of alcohol 5 formed in the reaction of ketone 2 with dissolved oxygen in methanol.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Therapeutic innovation targetting inflammation

Submission date :

2019-05-17T13:31:36Z