Antioxidant Activity of New Benzo[de]quinolines ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Antioxidant Activity of New Benzo[de]quinolines and Lactams: 2D-Quantitative Structure-Activity Relationships
Author(s) :
Ghinet, Alina [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Farce, Amaury [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Oudir, Souhila [Auteur]
Pommery, Jean [Auteur]
Vamecq, Joseph [Auteur]
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Henichart, Jean-Pierre [Auteur]
Rigo, Benoit [Auteur]
Gautret, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Farce, Amaury [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Oudir, Souhila [Auteur]
Pommery, Jean [Auteur]
Vamecq, Joseph [Auteur]
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Henichart, Jean-Pierre [Auteur]
Rigo, Benoit [Auteur]
Gautret, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Journal title :
Medicinal chemistry (Shariqah (United Arab Emirates))
Abbreviated title :
J. Med. Chem.
Volume number :
8
Pages :
942-946
Publication date :
2012-09-01
ISSN :
1573-4064
English keyword(s) :
benzo[de]quinoline
antioxidant agent
2D-QSAR
Lactam
hydroxyketolactam
antioxidant agent
2D-QSAR
Lactam
hydroxyketolactam
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
In order to predict the antioxidant activity of 7 polycyclic lactams, a two dimensional quantitative-structure activity relationships (2D-QSAR) study based on a 5-descriptor model was performed. The synthetic compounds ...
Show more >In order to predict the antioxidant activity of 7 polycyclic lactams, a two dimensional quantitative-structure activity relationships (2D-QSAR) study based on a 5-descriptor model was performed. The synthetic compounds built from a condensed lactam scaffold were screened for their abilities to inhibit the autoxidation of pyrogallol, a superoxide anion radical-dependent process. The ketone 2 (8,9-dihydro-7H-benzo[de]pyrrolo[1,2-a]quinoline-7,10(7aH)-dione) exhibited the most potent antioxidant activity in vitro. The oxidation mechanism was proved by the isolation and characterization of alcohol 5 formed in the reaction of ketone 2 with dissolved oxygen in methanol.Show less >
Show more >In order to predict the antioxidant activity of 7 polycyclic lactams, a two dimensional quantitative-structure activity relationships (2D-QSAR) study based on a 5-descriptor model was performed. The synthetic compounds built from a condensed lactam scaffold were screened for their abilities to inhibit the autoxidation of pyrogallol, a superoxide anion radical-dependent process. The ketone 2 (8,9-dihydro-7H-benzo[de]pyrrolo[1,2-a]quinoline-7,10(7aH)-dione) exhibited the most potent antioxidant activity in vitro. The oxidation mechanism was proved by the isolation and characterization of alcohol 5 formed in the reaction of ketone 2 with dissolved oxygen in methanol.Show less >
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Research team(s) :
Therapeutic innovation targetting inflammation
Submission date :
2019-05-17T13:31:36Z