Titre :

High-resolution mass spectrometry: Theoretical and technological aspects

Auteur(s) :

Zarrouk, Eliès [Auteur]
Shimadzu Corporation
Lenski, Marie [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Bruno, Clément [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Imaging, Brain & Neuropsychiatry [iBraiN]
Thibert, Valérie [Auteur]
Thermo Fisher Scientific Inc.
Contreras, Paul [Auteur]
Privat, Kevin [Auteur]
SCIEX
Ameline, Alice [Auteur]
Institut de Médecine Légale [Strasbourg]
Fabresse, Nicolas [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]

Titre de la revue :

Toxicologie Analytique et Clinique

Nom court de la revue :

Toxicologie Analytique et Clinique

Numéro :

34

Pagination :

3-18

Éditeur :

Elsevier BV

Date de publication :

2022-01

ISSN :

2352-0078

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Over the past decade, time-of-flight (TOF) and Orbitrap™ (Thermo Fisher Scientific) mass spectrometers have aroused a growing interest, and we observed a progressive replacement of low-resolution mass spectrometers (LRMS) ...
Lire la suite >Over the past decade, time-of-flight (TOF) and Orbitrap™ (Thermo Fisher Scientific) mass spectrometers have aroused a growing interest, and we observed a progressive replacement of low-resolution mass spectrometers (LRMS) by high-resolution mass spectrometers (HRMS). Thanks to high mass accuracy, they provide an unambiguous identification and allow structural elucidation of unknown compounds. Furthermore, they offer new powerful acquisition modes based on untargeted screenings dependent or independent of previous information. These advances are of particular interest in the field of toxicology, and we observed an increasing number of HRMS presentations at scientific meetings, corresponding original papers, and review articles dealing with application HRMS. The aim of this study is to compare HRMS with respect to LRMS in toxicology, to detail and explain the physical and technological principles on which the TOF and the Orbitrap mass analyzers are based, the data acquisition modes and data processing methods. Finally, three applications in toxicology are detailed to highlight the interest of this technology in toxicology.Lire moins >

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Date de dépôt :

2024-04-18T11:57:40Z
2024-04-22T07:41:51Z