Title :

High-resolution mass spectrometry: Theoretical and technological aspects

Author(s) :

Zarrouk, Eliès [Auteur]
Shimadzu Corporation
Lenski, Marie [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Bruno, Clément [Auteur]
Imaging, Brain & Neuropsychiatry [iBraiN]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Thibert, Valérie [Auteur]
Thermo Fisher Scientific Inc.
Contreras, Paul [Auteur]
Privat, Kevin [Auteur]
SCIEX
Ameline, Alice [Auteur]
Institut de Médecine Légale [Strasbourg]
Fabresse, Nicolas [Auteur]
Hôpital de la Timone [CHU - APHM] [TIMONE]

Journal title :

Toxicologie Analytique et Clinique

Abbreviated title :

Toxicologie Analytique et Clinique

Volume number :

34

Pages :

3-18

Publisher :

Elsevier BV

Publication date :

2022-01

ISSN :

2352-0078

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Over the past decade, time-of-flight (TOF) and Orbitrap™ (Thermo Fisher Scientific) mass spectrometers have aroused a growing interest, and we observed a progressive replacement of low-resolution mass spectrometers (LRMS) ...
Show more >Over the past decade, time-of-flight (TOF) and Orbitrap™ (Thermo Fisher Scientific) mass spectrometers have aroused a growing interest, and we observed a progressive replacement of low-resolution mass spectrometers (LRMS) by high-resolution mass spectrometers (HRMS). Thanks to high mass accuracy, they provide an unambiguous identification and allow structural elucidation of unknown compounds. Furthermore, they offer new powerful acquisition modes based on untargeted screenings dependent or independent of previous information. These advances are of particular interest in the field of toxicology, and we observed an increasing number of HRMS presentations at scientific meetings, corresponding original papers, and review articles dealing with application HRMS. The aim of this study is to compare HRMS with respect to LRMS in toxicology, to detail and explain the physical and technological principles on which the TOF and the Orbitrap mass analyzers are based, the data acquisition modes and data processing methods. Finally, three applications in toxicology are detailed to highlight the interest of this technology in toxicology.Show less >

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2024-04-18T11:57:40Z
2024-04-22T07:41:51Z