Coumarin-poly(2-oxazoline)s as synergetic ...
Document type :
Article dans une revue scientifique: Article original
Permalink :
Title :
Coumarin-poly(2-oxazoline)s as synergetic and protein-undetected nanovectors for photodynamic therapy
Author(s) :
Heaugwane, Diana [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Cerlati, Orélia [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Belkhir, Kedafi [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Benkhaled, Tarek [Auteur]
Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier [ICGM]
Catrouillet, Sylvain [Auteur]
Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier [ICGM]
Fabing, Isabelle [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Claparols, Catherine [Auteur]
Institut de Chimie de Toulouse [ICT]
Vedrenne, Marc [Auteur]
Institut de Chimie de Toulouse [ICT]
Goudounèche, Dominique [Auteur]
Centre de Microscopie Électronique Appliquée à la Biologie [CMEAB]
Payré, Bruno [Auteur]
Centre de Microscopie Électronique Appliquée à la Biologie [CMEAB]
Bona, Beatrice Lucia [Auteur]
Politecnico di Milano [Milan] [POLIMI]
Tosi, Alice [Auteur]
Politecnico di Milano [Milan] [POLIMI]
Baldelli Bombelli, Francesca [Auteur]
Politecnico di Milano [Milan] [POLIMI]
Vicendo, Patricia [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Lapinte, Vincent [Auteur]
Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier [ICGM]
Lonetti, Barbara [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Mingauto, Anne-Françoise [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Gibot, Laure [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Université Toulouse III - Paul Sabatier [UT3]
Cerlati, Orélia [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Belkhir, Kedafi [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Benkhaled, Tarek [Auteur]
Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier [ICGM]
Catrouillet, Sylvain [Auteur]
Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier [ICGM]
Fabing, Isabelle [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Claparols, Catherine [Auteur]
Institut de Chimie de Toulouse [ICT]
Vedrenne, Marc [Auteur]
Institut de Chimie de Toulouse [ICT]
Goudounèche, Dominique [Auteur]
Centre de Microscopie Électronique Appliquée à la Biologie [CMEAB]
Payré, Bruno [Auteur]
Centre de Microscopie Électronique Appliquée à la Biologie [CMEAB]
Bona, Beatrice Lucia [Auteur]
Politecnico di Milano [Milan] [POLIMI]
Tosi, Alice [Auteur]
Politecnico di Milano [Milan] [POLIMI]
Baldelli Bombelli, Francesca [Auteur]
Politecnico di Milano [Milan] [POLIMI]
Vicendo, Patricia [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Lapinte, Vincent [Auteur]
Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier [ICGM]
Lonetti, Barbara [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Mingauto, Anne-Françoise [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Gibot, Laure [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Journal title :
International Journal of Pharmaceutics
Volume number :
658
Pages :
124186
Publication date :
2024-06-10
Article status :
Publié
ISSN :
0378-5173
English keyword(s) :
Polymer
Self-assemblies
Poly(2-oxazoline)
Photodynamic therapy (PDT)
Coumarin
Protein corona
Self-assemblies
Poly(2-oxazoline)
Photodynamic therapy (PDT)
Coumarin
Protein corona
HAL domain(s) :
Chimie/Matériaux
Chimie/Polymères
Chimie/Polymères
English abstract : [en]
Because of the difficult challenges of nanopharmaceutics, the development of a variety of nanovectors is still highly desired. Photodynamic therapy, which uses a photosensitizer to locally produce reactive oxygen species ...
Show more >Because of the difficult challenges of nanopharmaceutics, the development of a variety of nanovectors is still highly desired. Photodynamic therapy, which uses a photosensitizer to locally produce reactive oxygen species to kill the undesired cells, is a typical example for which encapsulation has been shown to be beneficial. The present work describes the use of coumarin-functionalized polymeric nanovectors based on the self-assembly of amphiphilic poly(2-oxazoline)s. Encapsulation of pheophorbide a, a known PDT photosensitizer, is shown to lead to an increased efficiency compared to the un-encapsulated version. Interestingly, the presence of coumarin both enhances the desired photocytotoxicity and enables the crosslinking of the vectors. Various nanovectors are examined, differing by their size, shape and hydrophilicity. Their behaviour in PDT protocols on HCT-116 cells monolayers is described, the influence of their crosslinking commented. Furthermore, the formation of a protein corona is assessed.Show less >
Show more >Because of the difficult challenges of nanopharmaceutics, the development of a variety of nanovectors is still highly desired. Photodynamic therapy, which uses a photosensitizer to locally produce reactive oxygen species to kill the undesired cells, is a typical example for which encapsulation has been shown to be beneficial. The present work describes the use of coumarin-functionalized polymeric nanovectors based on the self-assembly of amphiphilic poly(2-oxazoline)s. Encapsulation of pheophorbide a, a known PDT photosensitizer, is shown to lead to an increased efficiency compared to the un-encapsulated version. Interestingly, the presence of coumarin both enhances the desired photocytotoxicity and enables the crosslinking of the vectors. Various nanovectors are examined, differing by their size, shape and hydrophilicity. Their behaviour in PDT protocols on HCT-116 cells monolayers is described, the influence of their crosslinking commented. Furthermore, the formation of a protein corona is assessed.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Other project(s) or funding source(s) :
Occitanie Region and EU, the project FEDER LR0021768: Pheophotodyn
Administrative institution(s) :
Université de Lille
CNRS
INRAE
ENSCL
CNRS
INRAE
ENSCL
Collections :
Research team(s) :
Ingénierie des Systèmes Polymères
Submission date :
2024-05-06T11:07:53Z
2024-05-06T19:47:36Z
2024-05-13T09:56:10Z
2024-05-06T19:47:36Z
2024-05-13T09:56:10Z