Farming activities and risk of inflammatory ...
Document type :
Article dans une revue scientifique: Article original
DOI :
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Title :
Farming activities and risk of inflammatory bowel disease: a French nationwide population-based cohort study.
Author(s) :
Petit, Pascal [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Leroyer, Ariane [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Chamot, Sylvain [Auteur]
CHU Amiens-Picardie
Fumery, Mathurin [Auteur]
CHU Amiens-Picardie
Université de Picardie Jules Verne [UPJV]
Bonneterre, Vincent [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Leroyer, Ariane [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Chamot, Sylvain [Auteur]
CHU Amiens-Picardie
Fumery, Mathurin [Auteur]

CHU Amiens-Picardie
Université de Picardie Jules Verne [UPJV]
Bonneterre, Vincent [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Journal title :
Journal of Crohn's and Colitis
Abbreviated title :
J Crohns Colitis
Publisher :
Oxford Academic
Publication date :
2024-04-16
ISSN :
1876-4479
English keyword(s) :
Environmental epidemiology and health surveillance
agricultural exposome
digital environmental and public health
agricultural exposome
digital environmental and public health
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background and Aims
Epidemiological data regarding inflammatory bowel disease [IBD] are lacking, in particular for occupationally exposed populations. We investigated whether, among the entire French farm manager [FM] ...
Show more >Background and Aims Epidemiological data regarding inflammatory bowel disease [IBD] are lacking, in particular for occupationally exposed populations. We investigated whether, among the entire French farm manager [FM] workforce, certain agricultural activities are more strongly associated with IBD than others. Methods Nationwide, population-based, insurance claims and electronic health records from all FMs who worked at least once over the period 2002–2016 were used [n = 1 088 561, 69% males]. The outcome measure was the association between 26 farming activities and the risk of IBD, Crohn’s disease [CD], and ulcerative colitis [UC], measured as hazard ratios [HRs], after adjusting for age, sex, pre-existing medical comorbidities, and farm location. The time to first chronic disease declaration was used as the underlying time scale. A model was generated for every activity and disease, using a reference group comprising all FMs who abstained from the specified activity from 2002 to 2016. Results There were 1752 IBD cases, with 704 CD [40.2%] and 1048 UC [59.8%] cases, respectively. Elevated HRs were observed for fruit arboriculture [HR from 1.17 to 1.52] and dairy farming [HR from 1.22 to 1.46] for all IBD, in crop farming for CD only (HR = 1.26, 95% confidence interval [CI]: 1.06–1.49), and in shellfish farming [HR from 2.12 to 2.51] for both CD and IBD. Conclusions Further research regarding specific farming activities and exposures likely to modify the microbiota [eg, pesticides, pathogens] is required to identify potential occupational risk factors [agricultural exposome] for IBD. Exposure to Mycobacterium avium subspecies paratuberculosis, Cryptosporidium, environmental toxins, micro/nanoplastics, and pesticides represents promising research avenues.Show less >
Show more >Background and Aims Epidemiological data regarding inflammatory bowel disease [IBD] are lacking, in particular for occupationally exposed populations. We investigated whether, among the entire French farm manager [FM] workforce, certain agricultural activities are more strongly associated with IBD than others. Methods Nationwide, population-based, insurance claims and electronic health records from all FMs who worked at least once over the period 2002–2016 were used [n = 1 088 561, 69% males]. The outcome measure was the association between 26 farming activities and the risk of IBD, Crohn’s disease [CD], and ulcerative colitis [UC], measured as hazard ratios [HRs], after adjusting for age, sex, pre-existing medical comorbidities, and farm location. The time to first chronic disease declaration was used as the underlying time scale. A model was generated for every activity and disease, using a reference group comprising all FMs who abstained from the specified activity from 2002 to 2016. Results There were 1752 IBD cases, with 704 CD [40.2%] and 1048 UC [59.8%] cases, respectively. Elevated HRs were observed for fruit arboriculture [HR from 1.17 to 1.52] and dairy farming [HR from 1.22 to 1.46] for all IBD, in crop farming for CD only (HR = 1.26, 95% confidence interval [CI]: 1.06–1.49), and in shellfish farming [HR from 2.12 to 2.51] for both CD and IBD. Conclusions Further research regarding specific farming activities and exposures likely to modify the microbiota [eg, pesticides, pathogens] is required to identify potential occupational risk factors [agricultural exposome] for IBD. Exposure to Mycobacterium avium subspecies paratuberculosis, Cryptosporidium, environmental toxins, micro/nanoplastics, and pesticides represents promising research avenues.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
Institut Pasteur de Lille
CHU Lille
Institut Pasteur de Lille
Submission date :
2024-05-06T21:18:41Z
2024-06-12T08:07:10Z
2024-06-12T08:09:00Z
2024-06-12T08:07:10Z
2024-06-12T08:09:00Z
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