Identification of non-volatile non-intentionally ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Identification of non-volatile non-intentionally added substances from polyester food contact coatings and genotoxicity assessment of polyester coating's migrates.
Auteur(s) :
Hayrapetyan, Ruzanna [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Cariou, Ronan [Auteur]
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement [INRAE]
École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS]
Laboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA]
Platel, Anne [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Santos, Julie [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Huot, Ludovic [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Monneraye, Véronique [Auteur]
Chagnon, Marie-Christine [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Severin, Isabelle [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Equipe NuTox (LNC - U1231) [NUTOX]
Cariou, Ronan [Auteur]
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement [INRAE]
École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS]
Laboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA]
Platel, Anne [Auteur]
![refId](/themes/Mirage2//images/idref.png)
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Santos, Julie [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Huot, Ludovic [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Monneraye, Véronique [Auteur]
Chagnon, Marie-Christine [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Severin, Isabelle [Auteur]
Equipe NuTox (LNC - U1231) [NUTOX]
Titre de la revue :
Food Chem Toxicol
Nom court de la revue :
Food Chem Toxicol
Numéro :
185
Pagination :
114484
Éditeur :
Elsevier
Date de publication :
2024-01-29
ISSN :
1873-6351
Mot(s)-clé(s) en anglais :
Food contact materials
Polyester coatings
Hazard identification
Oligoesters
Food safety
Polyester coatings
Hazard identification
Oligoesters
Food safety
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Can's polyester coatings are intended to replace epoxy-phenolic ones due to rising safety concern regarding the potential release of bisphenol A under increased regulations and consumer pressure. In this study, hazard ...
Lire la suite >Can's polyester coatings are intended to replace epoxy-phenolic ones due to rising safety concern regarding the potential release of bisphenol A under increased regulations and consumer pressure. In this study, hazard linked to the migration of non-intentionally added substances from a single polyester-coated tin plate (5 batches) to canned food has been studied. Migration tests were performed using acetonitrile (ACN) and ethanol (EtOH) 95 %. Non-targeted analyses by liquid chromatography–high-resolution mass spectrometry revealed the presence of four cyclic oligoesters classified as Cramer class III substances with an estimated exposure (calculated for French population only) below the threshold of toxicological concern value of 1.5 μg/kg b.w./day, suggesting a no safety concern. Moreover, migrates were tested using in vitro genotoxicity DNA damage response (DDR) test and mini mutagenicity test (MMT) with different strains of S. Typhimurium using direct incorporation (TA100, TA98, TA102, TA1537) and pre-incubation (TA100, TA98) methods. Samples were negative in both bioassays suggesting the absence of genotoxicity/mutagenicity of the mixtures. To verify any false negative response due to matrix effect, migrates were spiked with corresponding positive controls in parallel with the MMT and the DDR test. No matrix effect was observed in these experimental conditions.Lire moins >
Lire la suite >Can's polyester coatings are intended to replace epoxy-phenolic ones due to rising safety concern regarding the potential release of bisphenol A under increased regulations and consumer pressure. In this study, hazard linked to the migration of non-intentionally added substances from a single polyester-coated tin plate (5 batches) to canned food has been studied. Migration tests were performed using acetonitrile (ACN) and ethanol (EtOH) 95 %. Non-targeted analyses by liquid chromatography–high-resolution mass spectrometry revealed the presence of four cyclic oligoesters classified as Cramer class III substances with an estimated exposure (calculated for French population only) below the threshold of toxicological concern value of 1.5 μg/kg b.w./day, suggesting a no safety concern. Moreover, migrates were tested using in vitro genotoxicity DNA damage response (DDR) test and mini mutagenicity test (MMT) with different strains of S. Typhimurium using direct incorporation (TA100, TA98, TA102, TA1537) and pre-incubation (TA100, TA98) methods. Samples were negative in both bioassays suggesting the absence of genotoxicity/mutagenicity of the mixtures. To verify any false negative response due to matrix effect, migrates were spiked with corresponding positive controls in parallel with the MMT and the DDR test. No matrix effect was observed in these experimental conditions.Lire moins >
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
Institut Pasteur de Lille
CHU Lille
Institut Pasteur de Lille
Date de dépôt :
2024-05-06T21:19:27Z
2024-06-12T07:20:08Z
2024-06-12T07:20:08Z