Title :

Prevalence and variability of siderophore production in the <i>Achromobacter</i> genus.

Author(s) :

Sorlin, P. [Auteur]
PHYSE: Pathogènes Hydriques, Santé, Environnement [PHYSE]
Brivet, E. [Auteur]
PHYSE: Pathogènes Hydriques, Santé, Environnement [PHYSE]
Jean-Pierre, V. [Auteur]
PHYSE: Pathogènes Hydriques, Santé, Environnement [PHYSE]
Centre Hospitalier Universitaire de Nîmes [CHU Nîmes]
Aujoulat, F. [Auteur]
PHYSE: Pathogènes Hydriques, Santé, Environnement [PHYSE]
Besse, A. [Auteur]
PHYSE: Pathogènes Hydriques, Santé, Environnement [PHYSE]
Dupont, C. [Auteur]
PHYSE: Pathogènes Hydriques, Santé, Environnement [PHYSE]
CHU Montpellier = Montpellier University Hospital
Chiron, R. [Auteur]
PHYSE: Pathogènes Hydriques, Santé, Environnement [PHYSE]
Jumas-Bilak, E. [Auteur]
PHYSE: Pathogènes Hydriques, Santé, Environnement [PHYSE]
Menetrey, Quentin [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Marchandin, H. [Auteur]
PHYSE: Pathogènes Hydriques, Santé, Environnement [PHYSE]

Journal title :

Microbiol Spectr

Abbreviated title :

Microbiol Spectr

Pages :

e0295323

Publication date :

2024-02-06

ISSN :

2165-0497

English keyword(s) :

cystic fibrosis
opportunistic pathogen
Achromobacter xylosoxidans
Achromobacter spp.
siderophores

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Achromobacter spp. are opportunistic pathogens of environmental origin increasingly isolated in patients with underlying conditions like cystic fibrosis (CF). Despite recent advances, their virulence factors remain ...
Show more >Achromobacter spp. are opportunistic pathogens of environmental origin increasingly isolated in patients with underlying conditions like cystic fibrosis (CF). Despite recent advances, their virulence factors remain incompletely studied, and siderophore production has not yet been investigated in this genus. The aim of this study was to evaluate the production of siderophores in a large collection of Achromobacter spp. and evaluate the variability according to the origin of the strain and species. A total of 163 strains were studied, including 128 clinical strains (CF and non-CF patients) and 35 strains of environmental origin. Siderophores were quantified by the liquid chrome azurol-sulphonate assay. Species were identified by nrdA gene-based phylogeny. Strains were assigned to 20 species, with Achromobacter xylosoxidans being the most represented (51.5% of strains). Siderophore production was observed in 72.4% of the strains, with amounts ranging from 10.1% to 90% siderophore units. A significantly higher prevalence of siderophore-producing strains and greater production of siderophores were observed for clinical strains compared with strains of environmental origin. Highly variable observations were made according to species: A. xylosoxidans presented unique characteristics (one of the highest prevalence of producing strains and highest amounts produced, particularly by CF strains). Siderophores are important factors for bacterial growth commonly produced by members of the Achromobacter genus. The significance of the observations made during this study must be further investigated. Indeed, the differences observed according to species and the origin of strains suggest that siderophores may represent important determinants of the pathophysiology of Achromobacter spp. infections and also contribute to the particular epidemiological success of A. xylosoxidans in human infections.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-05-06T21:51:01Z
2024-08-28T08:09:13Z