Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain.

Dupuis, Orlane; Girardie, Julien; Van Gaever, Melanie; Garnier, Philippe; Coq, Jacques-Olivier; Canu, Marie-Hélène; Dupont, Erwan

Document type :

Article dans une revue scientifique: Article original

DOI :

10.3390/ijms25073918

PMID :

38612728

Permalink :

http://hdl.handle.net/20.500.12210/114238

Title :

Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain.

Author(s) :

Dupuis, Orlane [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Girardie, Julien [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Van Gaever, Melanie [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Garnier, Philippe [Auteur]
Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] [CAPS]
Département Génie biologique [IUT de Dijon/Auxerre - université de Bourgogne]
Coq, Jacques-Olivier [Auteur]
Institut des Sciences du Mouvement Etienne Jules Marey [ISM]
Canu, Marie-Hélène [Auteur]

Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Dupont, Erwan [Auteur]

Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Journal title :

International Journal of Molecular Sciences

Abbreviated title :

Int J Mol Sci

Volume number :

Publication date :

2024-04-19

ISSN :

1422-0067

English keyword(s) :

muscle-brain dialogue
cerebrospinal fluid
blood
myokines
development

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

first_pagesettingsOrder Article Reprints Open AccessArticle Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain by Orlane Dupuis 1,Julien Girardie 1ORCID,Mélanie Van Gaever 1,Philippe ...
Show more >first_pagesettingsOrder Article Reprints Open AccessArticle Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain by Orlane Dupuis 1,Julien Girardie 1ORCID,Mélanie Van Gaever 1,Philippe Garnier 2,3,Jacques-Olivier Coq 4,5,Marie-Hélène Canu 1,*ORCID andErwan Dupont 1 1 Univ. Lille, Univ. Artois, Univ. Littoral Côte d’Opale, ULR 7369, URePSSS—Unité de Recherche Pluridisciplinaire Sport Santé Société, F-59000 Lille, France 2 INSERM UMR1093-CAPS, Université Bourgogne Franche-Comté, UFR Des Sciences de Santé, F-21000 Dijon, France 3 Département Génie Biologique, IUT, F-21000 Dijon, France 4 Institut des Sciences du Mouvement, UMR7287, Aix-Marseille Université, F-13000 Marseille, France 5 Centre National de la Recherche Scientifique (CNRS), UMR7287, F-13000 Marseille, France * Author to whom correspondence should be addressed. Int. J. Mol. Sci. 2024, 25(7), 3918; https://doi.org/10.3390/ijms25073918 Submission received: 5 February 2024 / Revised: 28 March 2024 / Accepted: 29 March 2024 / Published: 31 March 2024 (This article belongs to the Special Issue Molecular Research on the Effects of Mimicking Exercise on Brain Health) Downloadkeyboard_arrow_down Browse Figures Versions Notes Abstract Interaction with the environment appears necessary for the maturation of sensorimotor and cognitive functions in early life. In rats, a model of sensorimotor restriction (SMR) from postnatal day 1 (P1) to P28 has shown that low and atypical sensorimotor activities induced the perturbation of motor behavior due to muscle weakness and the functional disorganization of the primary somatosensory and motor cortices. In the present study, our objective was to understand how SMR affects the muscle–brain dialogue. We focused on irisin, a myokine secreted by skeletal muscles in response to exercise. FNDC5/irisin expression was determined in hindlimb muscles and brain structures by Western blotting, and irisin expression in blood and cerebrospinal fluid was determined using an ELISA assay at P8, P15, P21 and P28. Since irisin is known to regulate its expression, Brain-Derived Neurotrophic Factor (BDNF) levels were also measured in the same brain structures. We demonstrated that SMR increases FNDC5/irisin levels specifically in the soleus muscle (from P21) and also affects this protein expression in several brain structures (as early as P15). The BDNF level was increased in the hippocampus at P8. To conclude, SMR affects FNDC5/irisin levels in a postural muscle and in several brain regions and has limited effects on BDNF expression in the brain.Show less >

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Submission date :

2024-05-06T23:33:11Z
2024-06-05T10:00:21Z

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Except where otherwise noted, this item's license is described as Attribution 3.0 United States

Version	Link	Modification date
2	20.500.12210/114238*	2024-06-05T09:55:54Z
1	20.500.12210/114238.1	2024-05-06T23:33:11Z

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