Hexahydrocannabinol poisoning reported to ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Hexahydrocannabinol poisoning reported to French poison centres.
Author(s) :
Labadie, Magalie [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Nardon, A. [Auteur]
Castaing, N. [Auteur]
Bragança, C. [Auteur]
Daveluy, A. [Auteur]
Gaulier, Jean-Michel [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
El Balkhi, S. [Auteur]
Grenouillet, M. [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Nardon, A. [Auteur]
Castaing, N. [Auteur]
Bragança, C. [Auteur]
Daveluy, A. [Auteur]
Gaulier, Jean-Michel [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
El Balkhi, S. [Auteur]
Grenouillet, M. [Auteur]
Journal title :
Clinical toxicology (Philadelphia, Pa.)
Abbreviated title :
Clin Toxicol (Phila)
Volume number :
62
Pages :
112-119
Publisher :
Taylor & Francis Online
Publication date :
2024-03-05
ISSN :
1556-9519
English keyword(s) :
Hexahydrocannabinol
poison centre
poisoning
new psychoactive substances
cannabinoid
poison centre
poisoning
new psychoactive substances
cannabinoid
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Introduction
Hexahydrocannabinol is a hexahydro derivative of cannabinol. Poisoning with hexahydrocannabinol was first observed in Europe in May 2022.
Method
This is a retrospective observational study of cases of ...
Show more >Introduction Hexahydrocannabinol is a hexahydro derivative of cannabinol. Poisoning with hexahydrocannabinol was first observed in Europe in May 2022. Method This is a retrospective observational study of cases of self-reported hexahydrocannabinol exposure reported to French poison centres between 1 January 2022 and 31 May 2023. Results There were 37 cases, including 19 in May 2023. The median age of the patients was 36 (interquartile range 28–43) years, and most were men. Eight patients had a history of substance use disorder. The route of exposure was ingestion in 24, inhalation (smoking or vaping) in 10, inhalation and ingestion in two and sublingual in one. Clinical features were neurological (85 per cent), cardiovascular (61 per cent), gastrointestinal (33 per cent), psychiatric (27 per cent) and ocular (21 per cent). Fifty-nine per cent of the patients were hospitalized. In four patients, the Poisoning Severity Score was 0 (asymptomatic); in 15 patients, the Score was 1 (minor); in 16, the Score was 2 (moderate); and in two cases, the Score was 3 (severe). In 70 per cent of patients, the outcome was known, and all recovered. Testing of biological samples was only undertaken in six cases. Five patients had positive blood or urine tests for hexahydrocannabinol; in two patients, tetrahydrocannabinol and metabolites were also detected. In addition, there was an additional patient in whom Δ8- and Δ9-tetrahydrocannabinol was detected in the substances used. Discussion Clinical effects reported in this series included neuropsychiatric and somatic effects. Whilst these cases related to self-reported hexahydrocannabinol use, it is likely that tetrahydrocannabinol use also contributed to the effects in a substantial proportion of cases. This study has some limitations, such as the lack of available information due to the retrospective nature of the study. As a result, it probably overestimates the number of moderate and severe cases due to under-reporting of cases of little or no severity. Analysis of the patient’s blood and urine was performed only in six patients, so we cannot be certain that the products consumed by the other patients were hexahydrocannabinol. Conclusion The clinical effects attributed to hexahydrocannabinol were neurological, cardiovascular, gastrointestinal, psychiatric and ocular predominantly and were sometimes serious.Show less >
Show more >Introduction Hexahydrocannabinol is a hexahydro derivative of cannabinol. Poisoning with hexahydrocannabinol was first observed in Europe in May 2022. Method This is a retrospective observational study of cases of self-reported hexahydrocannabinol exposure reported to French poison centres between 1 January 2022 and 31 May 2023. Results There were 37 cases, including 19 in May 2023. The median age of the patients was 36 (interquartile range 28–43) years, and most were men. Eight patients had a history of substance use disorder. The route of exposure was ingestion in 24, inhalation (smoking or vaping) in 10, inhalation and ingestion in two and sublingual in one. Clinical features were neurological (85 per cent), cardiovascular (61 per cent), gastrointestinal (33 per cent), psychiatric (27 per cent) and ocular (21 per cent). Fifty-nine per cent of the patients were hospitalized. In four patients, the Poisoning Severity Score was 0 (asymptomatic); in 15 patients, the Score was 1 (minor); in 16, the Score was 2 (moderate); and in two cases, the Score was 3 (severe). In 70 per cent of patients, the outcome was known, and all recovered. Testing of biological samples was only undertaken in six cases. Five patients had positive blood or urine tests for hexahydrocannabinol; in two patients, tetrahydrocannabinol and metabolites were also detected. In addition, there was an additional patient in whom Δ8- and Δ9-tetrahydrocannabinol was detected in the substances used. Discussion Clinical effects reported in this series included neuropsychiatric and somatic effects. Whilst these cases related to self-reported hexahydrocannabinol use, it is likely that tetrahydrocannabinol use also contributed to the effects in a substantial proportion of cases. This study has some limitations, such as the lack of available information due to the retrospective nature of the study. As a result, it probably overestimates the number of moderate and severe cases due to under-reporting of cases of little or no severity. Analysis of the patient’s blood and urine was performed only in six patients, so we cannot be certain that the products consumed by the other patients were hexahydrocannabinol. Conclusion The clinical effects attributed to hexahydrocannabinol were neurological, cardiovascular, gastrointestinal, psychiatric and ocular predominantly and were sometimes serious.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
Institut Pasteur de Lille
CHU Lille
Institut Pasteur de Lille
Submission date :
2024-05-15T21:20:04Z
2024-06-12T08:50:37Z
2024-06-12T08:50:37Z