Title :

The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex

Author(s) :

Makhani, Naila [Auteur]
Lebrun-Frenay, Christine [Auteur]
Siva, Aksel [Auteur]
Shabanova, Veronika [Auteur]
Wassmer, Evangeline [Auteur]
Santoro, Jonathan D. [Auteur]
Narula, Sona [Auteur]
Brenton, J. Nicholas [Auteur]
Mar, Soe [Auteur]
Durand-Dubief, Françoise [Auteur]
Zephir, Helene [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Mathey, Guillaume [Auteur]
Rojas, Juan I. [Auteur]
De Seze, Jérôme [Auteur]
Tenembaum, Silvia [Auteur]
Stone, Robert Thompson [Auteur]
Casez, Olivier [Auteur]
Carra-Dallière, Clarisse [Auteur]
Neuteboom, Rinze F. [Auteur]
Ahsan, Nusrat [Auteur]
Arroyo, Hugo A. [Auteur]
Cabre, Philippe [Auteur]
Gombolay, Grace [Auteur]
Inglese, Matilde [Auteur]
Louapre, Celine [Auteur]
Margoni, Monica [Auteur]
Palavra, Filipe [Auteur]
Pohl, Daniela [Auteur]
Reich, Daniel S. [Auteur]
Ruet, Aurélie [Auteur]
Thouvenot, Eric [Auteur]
Timby, Niklas [Auteur]
Tintore, Mar [Auteur]
Uygunoglu, Ugur [Auteur]
Vargas, Wendy [Auteur]
Venkateswaran, Sunita [Auteur]
Verhelst, Helene [Auteur]
Wickstrom, Ronny [Auteur]
Azevedo, Christina J. [Auteur]
Kantarci, Orhun [Auteur]
Shapiro, Eugene D. [Auteur]
Okuda, Darin T. [Auteur]
Pelletier, Daniel [Auteur]

Journal title :

Journal of Neurology

Abbreviated title :

J Neurol

Volume number :

271

Pages :

4019–4027

Publisher :

Springer Verlag

Publication date :

2024-04-02

ISSN :

1432-1459

English keyword(s) :

Children
Multiple sclerosis
Radiologically isolated syndrome
Pediatric
MRI

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
Sciences cognitives/Neurosciences

English abstract : [en]

Background : Cerebrospinal fluid (CSF) and spinal MRIs are often obtained in children with the radiologically isolated syndrome (RIS) for diagnosis and prognosis. Factors affecting the frequency and timing of these tests ...
Show more >Background : Cerebrospinal fluid (CSF) and spinal MRIs are often obtained in children with the radiologically isolated syndrome (RIS) for diagnosis and prognosis. Factors affecting the frequency and timing of these tests are unknown. Objective : To determine whether age or sex were associated with (1) having CSF or spinal MRI obtained or (2) the timing of these tests. Methods : We analyzed children (≤ 18 y) with RIS enrolled in an international longitudinal study. Index scans met 2010/2017 multiple sclerosis (MS) MRI criteria for dissemination in space (DIS). We used Fisher’s exact test and multivariable logistic regression (covariates = age, sex, MRI date, MRI indication, 2005 MRI DIS criteria met, and race). Results : We included 103 children with RIS (67% girls, median age = 14.9 y). Children ≥ 12 y were more likely than children < 12 y to have CSF obtained (58% vs. 21%, adjusted odds ratio [AOR] = 4.9, p = 0.03). Pre-2017, girls were more likely than boys to have CSF obtained (n = 70, 79% vs. 52%, AOR = 4.6, p = 0.01), but not more recently (n = 30, 75% vs. 80%, AOR = 0.2, p = 0.1; p = 0.004 for interaction). Spinal MRIs were obtained sooner in children ≥ 12 y (median 11d vs. 159d, p = 0.03). Conclusions : Younger children with RIS may be at continued risk for misdiagnosis and misclassification of MS risk. Consensus guidelines are needed.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Neuroinflammation & Multiple Sclerosis (NEMESIS)

Submission date :

2024-05-15T21:39:43Z
2025-02-26T15:30:13Z