Titre :

Results and perinatal outcomes from 189 ICSI cycles of couples with asthenozoospermic men and flagellar defects assessed by transmission electron microscopy.

Auteur(s) :

Boursier, Angele [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Boudry, Augustin [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Mitchell, Valérie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Loyens, Anne [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Rives, Nathalie [Auteur]
Université de Rouen Normandie [UNIROUEN]
Neuroendocrine, Endocrine and Germinal Differentiation Communication [NorDic]
Moerman, Alexandre [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Thomas, Lucie [Auteur]
Sorbonne Université [SU]
Maladies génétiques d'expression pédiatrique [U933]
Escudier, Estelle [Auteur]
Toure, Amina [Auteur]
Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) [IAB]
Whitfield, Marjorie [Auteur]
Coutton, Charles [Auteur]
Martinez, Guillaume [Auteur]
Ray, Pierre F. [Auteur]
Kherraf, Zine-Eddine [Auteur]
Viville, Stéphane [Auteur]
Laboratoire de Génétique Médicale [LGM]
Institut de génétique médicale d’Alsace [IGMA]
Legendre, Marie [Auteur]
Smol, Thomas [Auteur]
Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Robin, Geoffroy [Auteur]
Université de Lille
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Barbotin, Anne-Laure [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lille Neurosciences & Cognition - U 1172 [LilNCog]

Titre de la revue :

Reproductive BioMedicine Online

Nom court de la revue :

Reprod Biomed Online

Numéro :

47

Pagination :

103328

Date de publication :

2023-09-25

ISSN :

1472-6491

Mot(s)-clé(s) en anglais :

Asthenozoospermia
ICSI
Electron microscopy
Ultrastructural flagellar defects

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Research question Do patients presenting with flagella ultrastructural defects as assessed by electron microscopy, and defined within three phenotypes (dysplasia of the fibrous sheath [DFS], primary flagellar dyskinesia ...
Lire la suite >Research question Do patients presenting with flagella ultrastructural defects as assessed by electron microscopy, and defined within three phenotypes (dysplasia of the fibrous sheath [DFS], primary flagellar dyskinesia [PFD] and non-specific flagellar abnormalities [NSFA]), have decreased chances of success in intracytoplasmic sperm injection (ICSI) or adverse obstetric and neonatal outcomes? Design Retrospective analysis of 189 ICSI cycles from 80 men with spermatozoa flagellum ultrastructural defects (DFS [n = 16]; PFD [n = 14]; NSFA [n = 50] compared with a control group (n = 97). Cycles were cumulatively analysed. All fresh and frozen embryo transfers resulting from each ICSI attempt were included. The effect of transmission electron microscopy (TEM) phenotype on the main ICSI outcomes was assessed by a multivariate logistic regression combined with a generalized linear mixed model to account for the non-independence of the observations. Results No predictive value of TEM phenotype was found on the main outcomes of ICSI, namely fertilization rates, pregnancy and delivery rates, and cumulative pregnancy and delivery rates. Cumulative pregnancy rates ranged from 29.0–43.3% in the different TEM phenotype subgroups compared with 36.8% in the control group. Cumulative live birth rates ranged from 24.6–36.7% compared with 31.4% in the control group. No increase was found in miscarriages, preterm births, low birth weights or birth abnormalities. Conclusions Data on the cumulative chances of success in ICSI of patients with ultrastructural flagellar defects, a rare cause of male infertility often associated with an underlying genetic cause, are reassuring, as are obstetrical and neonatal outcomes in this population.Lire moins >

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172
• Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2024-05-15T22:01:05Z
2024-07-01T15:01:33Z