Titre :

Optical coherence tomography angiography macular biomarkers of peripheral retinal ischemia in diabetic macular edema: secondary endpoints from the clinical study \"FOVEA\".

Auteur(s) :

Serra, R. [Auteur]
Università degli Studi di Sassari = University of Sassari [Sassari] [UNISS]

Coscas, F. [Auteur]
Boulet, J. F. [Auteur]
Cabral, D. [Auteur]
Tran, Thi-Ha-Chau [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Pinna, A. [Auteur]
Università degli Studi di Sassari = University of Sassari [Sassari] [UNISS]
Lupidi, M. [Auteur]
Polytechnic University of Marche / Università Politecnica delle Marche [UNIVPM]
Coscas, G. [Auteur]

Titre de la revue :

Graefe's Archive for Clinical and Experimental Ophthalmology

Nom court de la revue :

Graefes Arch Clin Exp Ophthalmol

Numéro :

262

Pagination :

1777–1783

Date de publication :

2024-01-22

ISSN :

1435-702X

Mot(s)-clé(s) en anglais :

Diabetic macular edema
Fractal dimension
Lacunarity
Peripheral retinal ischemia

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Purpose To investigate the relationship between the macular values of fractal dimension (FD) and lacunarity (LAC) on optical coherence tomography angiography (OCTA) images and the presence of peripheral retina non-perfusion ...
Lire la suite >Purpose To investigate the relationship between the macular values of fractal dimension (FD) and lacunarity (LAC) on optical coherence tomography angiography (OCTA) images and the presence of peripheral retina non-perfusion areas (NPAs) on fluorescein angiography (FA) in patients with treatment-naïve diabetic macular edema (DME). Methods Fifty patients with treatment-naïve DME underwent a full ophthalmic examination, including best-corrected visual acuity measurement, FA, spectral-domain optical coherence tomography, and OCTA. Specifically, FA was performed to detect the presence of retinal NPAs, whereas fractal OCTA analysis was used to determine macular FD and LAC values at the level of the superficial and deep capillary plexus (SCP and DCP). FA montage frames of the posterior pole and peripheral retina, as well as macular OCTA slabs of the SCP and DCP, were obtained. Results Thirty (60%) eyes with FA evidence of peripheral retinal NPAs in at least one quadrant showed significantly lower FD and higher LAC in both SCP and DCP, when compared with eyes presenting a well-perfused peripheral retina. Furthermore, macular FD and LAC values were found to be significantly associated with the extent of retinal NPAs. Conclusions Macular FD and LAC of both SCP and DCP seem to be strongly associated with the extent of peripheral retinal NPAs, thus suggesting that may be useful predictive biomarkers of peripheral ischemia in treatment-naïve DME eyes.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-06-11T21:01:33Z
2024-10-25T09:07:31Z