Titre :

A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France

Auteur(s) :

Boudet-Berquier, J. [Auteur]
Demattei, C. [Auteur]
Guldner, L. [Auteur]
Gallay, A. [Auteur]
Manouvrier, Sylvie [Auteur]
Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 [RADEME]
Botton, J. [Auteur]
Philippat, C. [Auteur]
Delva, F. [Auteur]
Bloch, J. [Auteur]
Semaille, C. [Auteur]
Odent, S. [Auteur]
Perthus, I. [Auteur]
Randrianaivo, H. [Auteur]
Babajko, S. [Auteur]
Barjat, T. [Auteur]
Beneteau, C. [Auteur]
Brennetot, N. [Auteur]
Garne, E. [Auteur]
Haddad, G. [Auteur]
Hocine, M. [Auteur]
Lacroix, I. [Auteur]
Leuraud, K. [Auteur]
Mench, M. [Auteur]
Morris, J. [Auteur]
Patrier, S. [Auteur]
Sartelet, A. [Auteur]
Verloes, A. [Auteur]
Bonaldi, C. [Auteur]
Le Barbier, M. [Auteur]
Gagnière, B. [Auteur]
Pépin, P. [Auteur]
Ollivier, R. [Auteur]
Bitoun, M. [Auteur]
King, L. [Auteur]
Guajardo-Villar, A. [Auteur]
Gomes, E. [Auteur]
Desenclos, J. C. [Auteur]
Regnault, N. [Auteur]
Benachi, A. [Auteur]

Titre de la revue :

European Journal of Epidemiology

Nom court de la revue :

Eur J Epidemiol

Éditeur :

Springer Verlag

Date de publication :

2024-04-27

ISSN :

0393-2990

Mot(s)-clé(s) en anglais :

Birth defects
Cluster
Congenital anomalies
Limb reduction defects
Environment
Spatiotemporal analyses

Discipline(s) HAL :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Santé publique et épidémiologie

Résumé en anglais : [en]

Introduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where ...
Lire la suite >Introduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where initial investigations had not identified any risk exposure. We share here the national approach we developed for managing suspicious clusters of the same group of congenital anomalies occurring in several areas. Methods: The SEC analysed the medical records of TURLD suspected cases and performed spatiotemporal analyses on confirmed cases. If the cluster was statistically significant and included at least three cases, the SEC reviewed exposures obtained from questionnaires, environmental databases, and a survey among farmers living near to cases’ homes concerning their plant product use. Results: After case re-ascertainment, no statistically significant cluster was observed in the first administrative areas. In the second area, a cluster of four children born in two nearby towns over two years was confirmed, but as with the initial investigations, no exposure to a known risk factor explaining the number of cases in excess was identified. In the third area, a cluster including just two cases born the same year in the same town was confirmed. Discussion: Our experience highlights that in the event of suspicious clusters occurring in different areas of a country, a coordinated and standardised approach should be preferred.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364

Date de dépôt :

2024-06-26T21:11:20Z
2024-07-11T09:58:08Z