Self-Immolative Polymers : A new way to ...
Document type :
Autre communication scientifique (congrès sans actes - poster - séminaire...): Communication dans un congrès sans actes
Permalink :
Title :
Self-Immolative Polymers : A new way to depolymerize macromolecular architectures, leading to innovative drug delivery vectors
Author(s) :
Achour, Roukaya [Orateur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Potier, Jonathan [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Woisel, Patrice [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Belkhir, Kedafi [Auteur correspondant]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Potier, Jonathan [Auteur]

Unité Matériaux et Transformations (UMET) - UMR 8207
Woisel, Patrice [Auteur]

Unité Matériaux et Transformations (UMET) - UMR 8207
Belkhir, Kedafi [Auteur correspondant]
Unité Matériaux et Transformations (UMET) - UMR 8207
Conference title :
IUPAC MACRO 2024 THE 50TH WORLD POLYMER CONGRESS
Conference organizers(s) :
Warwick Polymer Group
Macro Group UK
Macro Group UK
City :
Warwick
Country :
Royaume-Uni
Start date of the conference :
2024-07-01
HAL domain(s) :
Chimie/Matériaux
English abstract : [en]
Self-Immolative Polymers (SIPs) are stimuli-responsive macromolecules which undergo a fast cascade depolymerization reaction in response to the stimulus. This unique behavior allows the elaboration of temporary structures ...
Show more >Self-Immolative Polymers (SIPs) are stimuli-responsive macromolecules which undergo a fast cascade depolymerization reaction in response to the stimulus. This unique behavior allows the elaboration of temporary structures with high potential of use as drug delivery vectors. In this work, SIPs sensitive to both UV and NIR light have been developed. Amphiphilic macromolecular architectures were designed in order to ensure the formation of self-assemblies. The triggered depolymerization of the structures were monitored by different methods, proving the on-demand and controlled kinetics. These SIP-based structures are likely to overcome important barriers encountered in the field of drug delivery, such as the passive release of the drugs, and to provide On/Off release profiles.Show less >
Show more >Self-Immolative Polymers (SIPs) are stimuli-responsive macromolecules which undergo a fast cascade depolymerization reaction in response to the stimulus. This unique behavior allows the elaboration of temporary structures with high potential of use as drug delivery vectors. In this work, SIPs sensitive to both UV and NIR light have been developed. Amphiphilic macromolecular architectures were designed in order to ensure the formation of self-assemblies. The triggered depolymerization of the structures were monitored by different methods, proving the on-demand and controlled kinetics. These SIP-based structures are likely to overcome important barriers encountered in the field of drug delivery, such as the passive release of the drugs, and to provide On/Off release profiles.Show less >
Language :
Anglais
Peer reviewed article :
Non
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
INRAE
ENSCL
CNRS
INRAE
ENSCL
Collections :
Research team(s) :
Ingénierie des Systèmes Polymères
Submission date :
2024-07-05T11:28:13Z
2024-07-10T07:32:18Z
2024-07-10T07:32:18Z