Architecture, Function, Regulation, and ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
URL permanente :
Titre :
Architecture, Function, Regulation, and Evolution of α-Glucans Metabolic Enzymes in Prokaryotes
Auteur(s) :
Cifuente, Javier O. [Auteur]
University of the Basque Country = Euskal Herriko Unibertsitatea [UPV / EHU]
Colleoni, Christophe [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Kalscheuer, Rainer [Auteur]
Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
Guerin, Marcelo E. [Auteur]
Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] [CSIC]
University of the Basque Country = Euskal Herriko Unibertsitatea [UPV / EHU]
Colleoni, Christophe [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Kalscheuer, Rainer [Auteur]
Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
Guerin, Marcelo E. [Auteur]
Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] [CSIC]
Titre de la revue :
Chemical Reviews
Nom court de la revue :
Chem. Rev.
Numéro :
124
Pagination :
4863-4934
Éditeur :
American Chemical Society (ACS)
Date de publication :
2024-04-12
ISSN :
0009-2665
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
Bacteria have acquired sophisticated mechanisms for assembling and disassembling polysaccharides of different chemistry. α-d-Glucose homopolysaccharides, so-called α-glucans, are the most widespread polymers in nature being ...
Lire la suite >Bacteria have acquired sophisticated mechanisms for assembling and disassembling polysaccharides of different chemistry. α-d-Glucose homopolysaccharides, so-called α-glucans, are the most widespread polymers in nature being key components of microorganisms. Glycogen functions as an intracellular energy storage while some bacteria also produce extracellular assorted α-glucans. The classical bacterial glycogen metabolic pathway comprises the action of ADP-glucose pyrophosphorylase and glycogen synthase, whereas extracellular α-glucans are mostly related to peripheral enzymes dependent on sucrose. An alternative pathway of glycogen biosynthesis, operating via a maltose 1-phosphate polymerizing enzyme, displays an essential wiring with the trehalose metabolism to interconvert disaccharides into polysaccharides. Furthermore, some bacteria show a connection of intracellular glycogen metabolism with the genesis of extracellular capsular α-glucans, revealing a relationship between the storage and structural function of these compounds. Altogether, the current picture shows that bacteria have evolved an intricate α-glucan metabolism that ultimately relies on the evolution of a specific enzymatic machinery. The structural landscape of these enzymes exposes a limited number of core catalytic folds handling many different chemical reactions. In this Review, we present a rationale to explain how the chemical diversity of α-glucans emerged from these systems, highlighting the underlying structural evolution of the enzymes driving α-glucan bacterial metabolism.Lire moins >
Lire la suite >Bacteria have acquired sophisticated mechanisms for assembling and disassembling polysaccharides of different chemistry. α-d-Glucose homopolysaccharides, so-called α-glucans, are the most widespread polymers in nature being key components of microorganisms. Glycogen functions as an intracellular energy storage while some bacteria also produce extracellular assorted α-glucans. The classical bacterial glycogen metabolic pathway comprises the action of ADP-glucose pyrophosphorylase and glycogen synthase, whereas extracellular α-glucans are mostly related to peripheral enzymes dependent on sucrose. An alternative pathway of glycogen biosynthesis, operating via a maltose 1-phosphate polymerizing enzyme, displays an essential wiring with the trehalose metabolism to interconvert disaccharides into polysaccharides. Furthermore, some bacteria show a connection of intracellular glycogen metabolism with the genesis of extracellular capsular α-glucans, revealing a relationship between the storage and structural function of these compounds. Altogether, the current picture shows that bacteria have evolved an intricate α-glucan metabolism that ultimately relies on the evolution of a specific enzymatic machinery. The structural landscape of these enzymes exposes a limited number of core catalytic folds handling many different chemical reactions. In this Review, we present a rationale to explain how the chemical diversity of α-glucans emerged from these systems, highlighting the underlying structural evolution of the enzymes driving α-glucan bacterial metabolism.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CNRS
Équipe(s) de recherche :
Génétique microbienne
Date de dépôt :
2024-07-12T08:10:32Z
2024-08-21T14:31:21Z
2024-08-21T14:35:58Z
2024-08-21T14:46:53Z
2024-08-21T14:31:21Z
2024-08-21T14:35:58Z
2024-08-21T14:46:53Z
Fichiers
- P24.13 cifuente-et-al-2024-architecture-function-regulation-and-evolution-of-α-glucans-metabolic-enzymes-in-prokaryotes.pdf
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