Title :

Evolution of the large secreted gel-forming mucins.

Author(s) :

Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Aubert, J P [Auteur]
Porchet, N [Auteur]
Laine, A [Auteur]

Journal title :

Molecular Biology and Evolution

Abbreviated title :

Mol Biol Evol

Volume number :

17

Pages :

1175-84

Publication date :

2000-08-01

ISSN :

0737-4038

English keyword(s) :

Amino Acid Motifs
Amino Acid Sequence
Animals
Base Sequence
Evolution
Molecular
Exons
Genes
Humans
Introns
Molecular Sequence Data
Mucin 5AC
Mucin-5B
Mucins
Phylogeny
Sequence Alignment
Sequence Homology
Amino Acid
Sequence Homology
Nucleic Acid
von Willebrand Factor

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Mucins, the major component of mucus, contain tandemly repeated sequences that differ from one mucin to another. Considerable advances have been made in recent years in our knowledge of mucin genes. The availability of the ...
Show more >Mucins, the major component of mucus, contain tandemly repeated sequences that differ from one mucin to another. Considerable advances have been made in recent years in our knowledge of mucin genes. The availability of the complete genomic and cDNA sequences of MUC5B, one of the four human mucin genes clustered on chromosome 11, provides an exemplary model for studying the molecular evolution of large mucins. The emerging picture is one of expansion of mucin genes by gene duplications, followed by internal repeat expansion that strictly preserves frameshift. Computational and phylogenetic analyses have permitted the proposal of an evolutionary history of the four human mucin genes located on chromosome 11 from an ancestor gene common to the human von Willebrand factor gene and the suggestion of a model for the evolution of the repeat coding portion of the MUC5B gene from a hypothetical ancestral minigene. The characterization of MUC5B, a member of the large secreted gel-forming mucin family, offers a new model for the comparative study of the structure-function relationship within this important family.Show less >

Language :

Anglais

Audience :

Non spécifiée

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2019-07-09T09:04:18Z
2019-07-09T09:35:50Z