Titre :

Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study.

Auteur(s) :

Ulugut, Hulya [Auteur]
Bertoux, Maxime [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Younes, Kyan [Auteur]
Montembeault, Maxime [Auteur]
Fumagalli, Giorgio G. [Auteur]
Samanci, Bedia [Auteur]
Illán-Gala, Ignacio [Auteur]
Kuchcinski, Gregory [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Leroy, Mélanie [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Thompson, Jennifer C. [Auteur]
Kobylecki, Christopher [Auteur]
Santillo, Alexander F. [Auteur]
Englund, Elisabeth [Auteur]
Waldö, Maria Landqvist [Auteur]
Riedl, Lina [Auteur]
Van Den Stock, Jan [Auteur]
Vandenbulcke, Mathieu [Auteur]
Vandenberghe, Rik [Auteur]
Laforce Jr, Robert [Auteur]
Ducharme, Simon [Auteur]
Pressman, Peter S. [Auteur]
Caramelli, Paulo [Auteur]
De Souza, Leonardo Cruz [Auteur]
Takada, Leonel T. [Auteur]
Gurvit, Hakan [Auteur]
Hansson, Oskar [Auteur]
Diehl-Schmid, Janine [Auteur]
Galimberti, Daniela [Auteur]
Pasquier, Florence [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Miller, Bruce L. [Auteur]
Scheltens, Philip [Auteur]
Ossenkoppele, Rik [Auteur]
Van Der Flier, Wiesje M. [Auteur]
Barkhof, Frederik [Auteur]
Fox, Nick C. [Auteur]
Sturm, Virginia E. [Auteur]
Miyagawa, Toji [Auteur]
Whitwell, Jennifer L. [Auteur]
Boeve, Bradley [Auteur]
Rohrer, Jonathan D. [Auteur]
Gorno-Tempini, Maria Luisa [Auteur]
Josephs, Keith A. [Auteur]
Snowden, Julie [Auteur]
Warren, Jason D. [Auteur]
Rankin, Katherine P. [Auteur]
Pijnenburg, Yolande A. L. [Auteur]

Titre de la revue :

Alzheimer's & Dementia : the Journal of the Alzheimer's Association

Nom court de la revue :

Alzheimers Dement

Date de publication :

2024-07-10

ISSN :

1552-5279

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

INTRODUCTION Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish ...
Lire la suite >INTRODUCTION Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. RESULTS Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. Highlights - This project is the first international collaboration and largest reported cohort. - Further efforts are warranted for precise nomenclature reflecting neural mechanisms. - Our results will serve as a clinical guideline for early and accurate diagnoses.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-07-16T21:23:07Z
2024-08-22T10:23:28Z