Title :

Impact of fish oils on the outcomes of a mouse model of acute Pseudomonas aeruginosa pulmonary infection.

Author(s) :

Caron, Emilie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Sergent, Luce [Auteur]
Bartke, Nana [Auteur]
Husson, Marie-Odile [Auteur]
Duhamel, Alain [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
gottrand, frederic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

The British journal of nutrition

Abbreviated title :

Br J Nutr

Volume number :

113

Pages :

191-9

Publication date :

2015-01-28

ISSN :

1475-2662

English keyword(s) :

Animals
Bacterial Load
Cytokines
Dietary Supplements
Fatty Acids
Omega-3
Fish Oils
Fishes
Immunity
Innate
Immunity
Mucosal
Immunologic Factors
Liver
Lung
Male
Mice
Inbred C57BL
Neutrophil Infiltration
Permeability
Pneumonia
Bacterial
Pseudomonas Infections
Pseudomonas aeruginosa
Random Allocation
Respiratory Mucosa
Survival Analysis
Alkylglycerols
Inflammation
Pseudomonas aeruginosa infection
n-3 Long-chain PUFA

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium that causes pneumonia in immunocompromised humans and severe pulmonary damage in patients with cystic fibrosis. Imbalanced fatty acid incorporation in ...
Show more >Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium that causes pneumonia in immunocompromised humans and severe pulmonary damage in patients with cystic fibrosis. Imbalanced fatty acid incorporation in membranes, including increased arachidonic acid and decreased DHA concentrations, is known to play a critical role in chronic inflammation associated with bacterial infection. Other lipids, such as EPA and alkylglycerols, are also known to play a role in inflammation, particularly by stimulating the immune system, decreasing inflammation and inhibiting bacterial growth. In this context, the goal of the present study was to assess the effect of dietary DHA/EPA, in a 2:1 ratio, and alkylglycerols, as natural compounds extracted from oils of rays and chimeras, respectively, on the inflammatory reaction induced by P. aeruginosa pulmonary infection in mice. To this end, mice were fed with a control diet or isolipidic, isoenergetic diets prepared with oils enriched in DHA/EPA (2:1) or alkylglycerols for 5 weeks before the induction of acute P. aeruginosa lung infection by endotracheal instillation. In our model, DHA/EPA (2:1) significantly improved the survival of mice after infection, which was associated with the acceleration of bacterial clearance and the resolution of inflammation leading to the improvement of pulmonary injuries. By contrast, alkylglycerols did not affect the outcomes of P. aeruginosa infection. Our findings suggest that supplementation with ray oil enriched in DHA/EPA (2:1) can be considered as a preventive treatment for patients at risk for P. aeruginosa infection.Show less >

Language :

Anglais

Audience :

Non spécifiée

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-07-09T13:53:17Z
2019-07-10T08:57:41Z