(n-3) long-chain PUFA differentially affect ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
(n-3) long-chain PUFA differentially affect resistance to Pseudomonas aeruginosa infection of male and female cftr-/- mice.
Auteur(s) :
Tiesset, Hélène [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bernard, Henry [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bartke, Nana [Auteur]
Beermann, Christopher [Auteur]
Flachaire, Elisabeth [Auteur]
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
gottrand, frederic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Husson, Marie-Odile [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bernard, Henry [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bartke, Nana [Auteur]
Beermann, Christopher [Auteur]
Flachaire, Elisabeth [Auteur]
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
gottrand, frederic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Husson, Marie-Odile [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Titre de la revue :
The Journal of Nutrition
Nom court de la revue :
J Nutr
Numéro :
141
Pagination :
1101-7
Date de publication :
2011-06-01
ISSN :
1541-6100
Mot(s)-clé(s) en anglais :
Animals
Bronchoalveolar Lavage Fluid
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Cytokines
Dietary Supplements
Disease Susceptibility
Fatty Acids
Omega-3
Female
Humans
Inflammation Mediators
Lung
Male
Mice
Mice
129 Strain
Mice
Inbred C57BL
Mice
Inbred CFTR
Mice
Knockout
Opportunistic Infections
Pneumonia
Bacterial
Pseudomonas Infections
Sex Factors
Bronchoalveolar Lavage Fluid
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Cytokines
Dietary Supplements
Disease Susceptibility
Fatty Acids
Omega-3
Female
Humans
Inflammation Mediators
Lung
Male
Mice
Mice
129 Strain
Mice
Inbred C57BL
Mice
Inbred CFTR
Mice
Knockout
Opportunistic Infections
Pneumonia
Bacterial
Pseudomonas Infections
Sex Factors
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The aim of this study was to determine whether oral supplementation with EPA/DHA (10.5 and 5.1% of fat, respectively) could improve the outcome of pulmonary P. aeruginosa infection in cftr(-/-) mice compared with wild-type ...
Lire la suite >The aim of this study was to determine whether oral supplementation with EPA/DHA (10.5 and 5.1% of fat, respectively) could improve the outcome of pulmonary P. aeruginosa infection in cftr(-/-) mice compared with wild-type (Wt) mice similarly treated. Because gender could influence the susceptibility of cftr-deficient mice, results were analyzed by gender. Wt and (-/-) mice were randomized for 6 wk to consume a control or EPA/DHA diet, infected with endotracheal injection of 5 × 10(7) CFU/mouse of P. aeruginosa, and killed 24 h later. Cftr(-/-) mice were more susceptible to infection than were Wt mice; (-/-) males had more neutrophils (P < 0.01) and a higher keratinocyte-derived chemokine (KC) level (P < 0.05), and (-/-) females had greater lung injury and mortality (P < 0.05). Female (-/-) mice were more susceptible than (-/-) males with a higher mortality and lung injury (P < 0.05). The EPA/DHA diet reduced neutrophil numbers and KC and IL-6 levels (P < 0.05) in (-/-) males and reduced mortality rate (P < 0.001), lung permeability, and IL-6 level (P < 0.05) in (-/-) females compared with (-/-) mice fed the control diet. These results were associated with a reduction in the pulmonary bacterial load (P < 0.05), an increase in the EPA/DHA concentration in cell membranes of (-/-) males and females (P < 0.01), and an increased weight gain only in males compared with (-/-) mice fed the control diet (P < 0.01). In conclusion, EPA/DHA improves the host resistance of (-/-) mice, although the beneficial effect differed in males and females.Lire moins >
Lire la suite >The aim of this study was to determine whether oral supplementation with EPA/DHA (10.5 and 5.1% of fat, respectively) could improve the outcome of pulmonary P. aeruginosa infection in cftr(-/-) mice compared with wild-type (Wt) mice similarly treated. Because gender could influence the susceptibility of cftr-deficient mice, results were analyzed by gender. Wt and (-/-) mice were randomized for 6 wk to consume a control or EPA/DHA diet, infected with endotracheal injection of 5 × 10(7) CFU/mouse of P. aeruginosa, and killed 24 h later. Cftr(-/-) mice were more susceptible to infection than were Wt mice; (-/-) males had more neutrophils (P < 0.01) and a higher keratinocyte-derived chemokine (KC) level (P < 0.05), and (-/-) females had greater lung injury and mortality (P < 0.05). Female (-/-) mice were more susceptible than (-/-) males with a higher mortality and lung injury (P < 0.05). The EPA/DHA diet reduced neutrophil numbers and KC and IL-6 levels (P < 0.05) in (-/-) males and reduced mortality rate (P < 0.001), lung permeability, and IL-6 level (P < 0.05) in (-/-) females compared with (-/-) mice fed the control diet. These results were associated with a reduction in the pulmonary bacterial load (P < 0.05), an increase in the EPA/DHA concentration in cell membranes of (-/-) males and females (P < 0.01), and an increased weight gain only in males compared with (-/-) mice fed the control diet (P < 0.01). In conclusion, EPA/DHA improves the host resistance of (-/-) mice, although the beneficial effect differed in males and females.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Date de dépôt :
2019-07-09T14:01:21Z
2019-07-10T09:11:21Z
2019-07-10T09:11:21Z
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