Guided tissue regeneration membranes with ...
Document type :
Article dans une revue scientifique
Permalink :
Title :
Guided tissue regeneration membranes with controlled delivery properties of chlorhexidine by their functionalization with cyclodextrins
Author(s) :
Leprêtre, Stéphane [Auteur]
Boschin, F [Auteur]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Bria, Marc [Auteur]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Blanchemain, Nicolas [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Hildebrand, Hartmut Frederic [Auteur]
Morcellet, Michel [Auteur]
Delcourt Debruyne, Elisabeth [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Boschin, F [Auteur]
Tabary, Nicolas [Auteur]

Unité Matériaux et Transformations - UMR 8207 [UMET]
Bria, Marc [Auteur]

Martel, Bernard [Auteur]

Unité Matériaux et Transformations - UMR 8207 [UMET]
Blanchemain, Nicolas [Auteur]

Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Hildebrand, Hartmut Frederic [Auteur]
Morcellet, Michel [Auteur]
Delcourt Debruyne, Elisabeth [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Journal title :
Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume number :
57
Pages :
297-302
Publication date :
2007
HAL domain(s) :
Chimie/Matériaux
Chimie/Polymères
Chimie/Polymères
English abstract : [en]
In parodontology, guided tissue regeneration (GTR) is a new technique to cure periodontal lesions. Where the association of the GTR with an antimicrobial agent does not yield optimal results, we used the properties of ...
Show more >In parodontology, guided tissue regeneration (GTR) is a new technique to cure periodontal lesions. Where the association of the GTR with an antimicrobial agent does not yield optimal results, we used the properties of cyclodextrins (CDs) to improve the membrane used in RTG to control the release and to increase the quantity of antimicrobial agent stocked on the membrane. We successed in fixing 14%-wt of cyclodextrin polymer on polyvinylidene difluoride (PVDF) membranes thank to citric acid (CTR) as crosslinking agent. We studied the complexation of chlorhexidine diacetate (CHX), the antiseptic agent used in this study, with CDs in UV-spectrophotometry and ROESY NMR. We observed complexation of CHX by b, c, hydroxypropylated (HP) bCD. We studied the biological properties of the cyclodextrin polymer onto (PVDF) membranes and observed that the CDs-polymer is not harmful for the cells. Moreover it stimulates their growth with native CD. A kinetic of release of the CHX was performed. Raw membranes released all CHX stocked in few hours, whereas grafted membranes released more than tenfold this quantity during 60–80 days.Show less >
Show more >In parodontology, guided tissue regeneration (GTR) is a new technique to cure periodontal lesions. Where the association of the GTR with an antimicrobial agent does not yield optimal results, we used the properties of cyclodextrins (CDs) to improve the membrane used in RTG to control the release and to increase the quantity of antimicrobial agent stocked on the membrane. We successed in fixing 14%-wt of cyclodextrin polymer on polyvinylidene difluoride (PVDF) membranes thank to citric acid (CTR) as crosslinking agent. We studied the complexation of chlorhexidine diacetate (CHX), the antiseptic agent used in this study, with CDs in UV-spectrophotometry and ROESY NMR. We observed complexation of CHX by b, c, hydroxypropylated (HP) bCD. We studied the biological properties of the cyclodextrin polymer onto (PVDF) membranes and observed that the CDs-polymer is not harmful for the cells. Moreover it stimulates their growth with native CD. A kinetic of release of the CHX was performed. Raw membranes released all CHX stocked in few hours, whereas grafted membranes released more than tenfold this quantity during 60–80 days.Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
CNRS
INRA
ENSCL
CNRS
INRA
ENSCL
Collections :
Research team(s) :
Ingénierie des Systèmes Polymères
Submission date :
2019-07-18T12:59:08Z
2019-07-18T13:04:55Z
2019-07-18T13:17:02Z
2019-09-27T06:40:34Z
2019-07-18T13:04:55Z
2019-07-18T13:17:02Z
2019-09-27T06:40:34Z
Annexes
- s10847-006-9176-0
- Open access
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