Titre :

Guided tissue regeneration membranes with controlled delivery properties of chlorhexidine by their functionalization with cyclodextrins

Auteur(s) :

Leprêtre, Stéphane [Auteur]
Boschin, F [Auteur]
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Bria, Marc [Auteur]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Blanchemain, Nicolas [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Hildebrand, Hartmut Frederic [Auteur]
Morcellet, Michel [Auteur]
Delcourt Debruyne, Elisabeth [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]

Titre de la revue :

Journal of Inclusion Phenomena and Macrocyclic Chemistry

Numéro :

57

Pagination :

297-302

Date de publication :

2007

Discipline(s) HAL :

Chimie/Matériaux
Chimie/Polymères

Résumé en anglais : [en]

In parodontology, guided tissue regeneration (GTR) is a new technique to cure periodontal lesions. Where the association of the GTR with an antimicrobial agent does not yield optimal results, we used the properties of ...
Lire la suite >In parodontology, guided tissue regeneration (GTR) is a new technique to cure periodontal lesions. Where the association of the GTR with an antimicrobial agent does not yield optimal results, we used the properties of cyclodextrins (CDs) to improve the membrane used in RTG to control the release and to increase the quantity of antimicrobial agent stocked on the membrane. We successed in fixing 14%-wt of cyclodextrin polymer on polyvinylidene difluoride (PVDF) membranes thank to citric acid (CTR) as crosslinking agent. We studied the complexation of chlorhexidine diacetate (CHX), the antiseptic agent used in this study, with CDs in UV-spectrophotometry and ROESY NMR. We observed complexation of CHX by b, c, hydroxypropylated (HP) bCD. We studied the biological properties of the cyclodextrin polymer onto (PVDF) membranes and observed that the CDs-polymer is not harmful for the cells. Moreover it stimulates their growth with native CD. A kinetic of release of the CHX was performed. Raw membranes released all CHX stocked in few hours, whereas grafted membranes released more than tenfold this quantity during 60–80 days.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Ingénierie des Systèmes Polymères

Date de dépôt :

2019-07-18T12:59:08Z
2019-07-18T13:04:55Z
2019-07-18T13:17:02Z
2019-09-27T06:40:34Z