Title :

Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin

Author(s) :

Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Leprêtre, Stéphane [Auteur]
Boschin, François [Auteur]
Blanchemain, Nicolas [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Neut, Christel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Delcourt Debruyne, Elisabeth [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Morcellet, Michel [Auteur]
Hildebrand, Hartmut Frederic [Auteur]

Journal title :

Biomolecular Engineering

Volume number :

24

Pages :

472-476

Publication date :

2007

HAL domain(s) :

Chimie/Matériaux
Chimie/Polymères

English abstract : [en]

Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of ...
Show more >Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18 wt% increase of the supports. MX grafted membrane could capture 103 mg/g chlorhexidin digluconate(DigCHX) instead of 1 mg/g for a Virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. In vitro release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and b-CD grafted membranes. The antimicrobial activity was effective during more than 72 h.Show less >

Language :

Anglais

Audience :

Non spécifiée

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2019-07-18T13:10:45Z
2019-10-11T12:42:49Z