Functionalization of PVDF membranes with ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin
Auteur(s) :
Tabary, Nicolas [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Leprêtre, Stéphane [Auteur]
Boschin, François [Auteur]
Blanchemain, Nicolas [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Neut, Christel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Delcourt Debruyne, Elisabeth [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Morcellet, Michel [Auteur]
Hildebrand, Hartmut Frederic [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Leprêtre, Stéphane [Auteur]
Boschin, François [Auteur]
Blanchemain, Nicolas [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Neut, Christel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Delcourt Debruyne, Elisabeth [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Morcellet, Michel [Auteur]
Hildebrand, Hartmut Frederic [Auteur]
Titre de la revue :
Biomolecular Engineering
Numéro :
24
Pagination :
472-476
Date de publication :
2007
Discipline(s) HAL :
Chimie/Matériaux
Chimie/Polymères
Chimie/Polymères
Résumé en anglais : [en]
Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of ...
Lire la suite >Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18 wt% increase of the supports. MX grafted membrane could capture 103 mg/g chlorhexidin digluconate(DigCHX) instead of 1 mg/g for a Virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. In vitro release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and b-CD grafted membranes. The antimicrobial activity was effective during more than 72 h.Lire moins >
Lire la suite >Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18 wt% increase of the supports. MX grafted membrane could capture 103 mg/g chlorhexidin digluconate(DigCHX) instead of 1 mg/g for a Virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. In vitro release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and b-CD grafted membranes. The antimicrobial activity was effective during more than 72 h.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
CNRS
INRA
ENSCL
CNRS
INRA
ENSCL
Collections :
Équipe(s) de recherche :
Ingénierie des Systèmes Polymères
Date de dépôt :
2019-07-18T13:10:45Z
2019-10-11T12:42:49Z
2019-10-11T12:42:49Z