Title :

Evaluation of parenteral diluent contamination by caprolactam

Author(s) :

Curti, Christophe [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Institut de Chimie Radicalaire [ICR]
D’huart, Elise [Auteur]
Lamy, Edouard [Auteur]
Institut des Sciences du Mouvement Etienne Jules Marey [ISM]
Primas, Nicolas [Auteur]
Institut de Chimie Radicalaire [ICR]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Fersing, Cyril [Auteur]
Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
Institut régional de Cancérologie de Montpellier [ICM]
Bornet, Charleric [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Martin, Nathalie [Auteur]
Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Pourroy, Bertrand [Auteur]
Service Pharmacie [Hôpital de la Timone - APHM]
Vanelle, Patrice [Auteur]
Institut de Chimie Radicalaire [ICR]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]

Journal title :

American Journal of Health-System Pharmacy

Publisher :

American Society of Health-System Pharmacists

Publication date :

2024-07-30

ISSN :

1079-2082

HAL domain(s) :

Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Médicaments

English abstract : [en]

A leachable cyclic amide (caprolactam) can be found in normal saline (NS) and 5% dextrose in water (D5W) plastic bags widely used in clinical practice if they contain polyamide in a multilayer sheeting. This contamination ...
Show more >A leachable cyclic amide (caprolactam) can be found in normal saline (NS) and 5% dextrose in water (D5W) plastic bags widely used in clinical practice if they contain polyamide in a multilayer sheeting. This contamination and the parameters that could influence its content have never been studied in a public work such as a scientific publication.Two independent laboratories validated a caprolactam dosing method and studied contamination levels in several containers.Caprolactam content in multilayer polypropylene/polyamide/polypropylene plastic bags ranged from a mean (SD) of 5.43 (0.21) mg/L (D5W 1,000 mL) to 22.83 (1.26) mg/L (NS 50 mL). NS and D5W can be intravenously administered with a total daily dose of 3 L, corresponding to a minimal daily dose of 16.3 mg of caprolactam.The high levels of contamination we have reported and the possibility of administering caprolactam to high-risk patients (eg, neonates, the elderly) should make it imperative for pharmaceutical companies to communicate publicly on the safety of caprolactam.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Source :

Harvested from HAL